Genetic biologist, Fellow of Chinese Academy of Sciences, Fellow of TWAS. Professor and Director of Bio-X Institutes, Shanghai Jiao Tong University. Professor and Director of Institutes of Biomedical Scieces, Fudan University. Professor and PI of Shanghai Institute for Nutritional Sciences, SIBS, Chinese Academy of Sciences. Associate editor of “Biological Experiment and Medicine” and editors for more than 10 scientific journals. The chief scientist of the National 973 Program, member of the Expert Steering Committee for the 863 Programs. By now he has published over 300 peer-reviewed papers.

Molecular mechanisms underlying genetic disorders, including major monogenic and polygenic diseases of which psychiatric disorders are mainly focused on, nutrigenomics, pharmacogenomics, translational medicine, and DNA computing technology, etc.

1. Shi Y#*, Li Z#, Xu Q#, ……, He L*. Common Variants on 8p12 and 1q24.2 Confer Risk of Schizophrenia. Nat Genet. 2011;43(12):1224-7.

2. Chen P#, Pan D#, Fan C, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y *. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nat Nanotechnol. 2011;6(10):639-44.

3. Li R#, Fan W#, Tian G#, Zhu H#, He L#, Cai J#, ……, Wang J*. The sequence and de novo assembly of the giant pandagenome. Nature. 2010; 463(7279):311-7.

4. Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signaling capacity and range. Nature. 2009; 458(7242):1196-200.

5. O'Donovan MC, ……, He L, ……, Owen MJ. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40(9):1053-1055.

6. St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P*,  He L*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005; 294(5):557-62.

7. Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001; 28(4):386-8.

# Contributed equally to the paper * Corresponding author

Secretary of the Bioethics Committee of Bio-X Institutes of Shanghai Jiaotong University. BS-Nanjing Normal University, Ph.D-Fudan University, lecturer-Shanghai Medical College of Fudan University, research fellow-Harvard School of public health. Projects: Chinese National Science Foundation (No. 31101015), the scientific research foundation for the returned overseas, the Chinese Ministry of Education (No. 12Z102050009), and funding for Biomedical Multidisciplinary Research.

Cross-disorders of psychiatric illness and inflammation,investigation of genetic variants that influence traits related to these disorders with methods from epidemiology and population genetics, validation of these genetic variants with from molecular and cellular biology, and system bioloby.

1.Lei Cai*, Shao-Li Deng, Li Liang, Hui Pan, Jia Zhou, Mei-Yan Wang, Jun Yue, Chun-Ling Wan, Guang He, Lin He. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population (2013). Human Genetics. 132:265-273.

2.Lei Cai*, Wei Huang, Kuo-Chen Chou. Prostate cancer with variants in CYP17 and UGT2B17 genes: A meta-analysis (2012). Protein & Peptide Letters.19: 62-69.

3.Lei Cai*, Ying Wang, Jing-Fang Wang, Kuo-Chen Chou. Identification of proteins interacting with human SP110 during the process of viral infections (2011). Medicinal Chemistry. 7:121-126.

4.Lei Cai*, Hui Pan, Krzysztof Trzciński, Claudette M. Thompson, Qiang Wu and Igor Kramnik (2010). MYBBP1A: a new Ipr1's binding protein in mice. Molecular Biology Reports. 37: 3863-3868.

5.Lei Cai, Dongqing Zhang, Yeqing Shi, MK Oaks, Lishan Chen, Jianzhong Jin, Jie Qian, Fang Du, Ningli Li, Xinghai Han and Daming Ren (2005). Association of the CTLA-4 Gene with Rheumatoid Arthritis in Chinese Han Population. European Journal of Human Genetics. 13: 823-828.

6.Lei Cai, Guomei Tang, Lishan Chen, Bosheng Zhang, Sanduo Jiang and Daming Ren (2005). Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer’s disease patients. NeuroReport. 16: 1023-1026.

# Contributed equally to the paper * Corresponding author