Dr. Shengying Qin’s research works have been sponsored by National Key Project for Investigational New Drug, 863 Program ,NSFC and SMC program of Shanghai Jiao Tong University. Dr. Qin has published 20 papers and applied 6 patents. In addition, Dr. Qin has also developed the DNA chip technologies for personalized medicine and disease diagnosis of Chinese population, several of which have been applied in hospitals.

Development and application of microarray and next generation sequencing in high throughput technology for mechanism study of complex diseases, drug analysis and diagnostic research, including personalized medicine system study, gene expression and regulation study, genomic polymorphism analysis.

1．Gong X, Liu Y, Zhang X, Wei Z, Huo R, Shen L, He L, Qin S*，Systematic Functional Study of Cytochrome P450 2D6 Promoter Polymorphisms in the Chinese Han Population. PLos One.2013；8(2):p e57764.

2．Huang X, Chen L, Song W, Chen L, Niu J, Han X, Feng G, He L, Qin S*，Systematic Functional Characterization of Cytochrome P450 2E1 Promoter Variants in the Chinese Han Population. PLos One.2012;7(7):p e40883.

3．Huo R, Tang K, Wei Z, Shen L, Xiong Y, Wu X, Niu J, Han X, Tian Z, Yang L, Feng G, He L*, Qin S*，Genetic Polymorphisms in CYP2E1: Association with Schizophrenia Susceptibility and Risperidone Response in the Chinese Han Population. PLos One.2012;7(5):p e34809.

4. Xiong Y, Wang M, Fang K., Xing Q, Feng G, Shen L, He L, Qin S*, A systematic genetic polymorphism analysis of the CYP2C9 gene in four different geographical Han populations in mainland China. Genomics. 2011;97(5):277-81.

5. Tang K, Li X, Xing Q, Feng G, He Lin, Qin S*, Genetic polymorphism analysis of cytochrome P4502E1 in Chinese Han populations from four different geographic areas of Chinese Mainland. Genomics. 2010;95(4):224-9.

6. Qin S, Shen L, Zhang A, Xie J, Shen W, Chen L, Tang J, Xiong Y, Shi Y, Feng G, He L*,  Xing Q*. Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China. Genomics. 2008; 92:152-158.

7. Chen L#, Qin S#, Xie J, Tang J, Shen W, Zhao X, Shen L, He G, Feng G. He L, Xing Q*. Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China. Pharmacogenomics. 2008; 9(6): 691-702.

8. Zhao X#, Qin S#, Shi Y, Zhang A, Zhang J, Bian L, Wan C, Feng G, Gu N, Zhang G, He G*, He L*. Systematic study of association of four GABAergic genes, GAD1, GAD2, GABBR1 and GABRB2, with schizophrenia using a universal DNA microarray. Schizophr Res. 2007; 93:374-384.

9. Qin S#, Zhao X#, Pan Y, Liu J, Feng G, Fu J, Bao J, Zhang Z, He L*. An association study of the N-methyl-D-aspartate receptor NR1 subunit gene (GRIN1) and NR2B subunit gene (GRIN2B) in schizophrenia with universal DNA microarray. Eur J Hum Genet. 2005; 13(7):807-814.

# Contributed equally to the paper * Corresponding author

1. Zhao M #, Ma J #, Li M #, Zhu W #, Zhou W, Shen L, Wu H, Zhang N, Wu S, Fu C, Li X, Yang K, Tang T, Shen R, He L, Huai C *, Qin S*. Different responses to risperidone treatment in Schizophrenia: a multicenter genome-wide association and whole exome sequencing joint study, Translational Psychiatry, 2022, 12(1)
      2.Zhou W #, Sun J #, Huai C #, Liu Y, Chen L, Yi Z, Lv Q, Song C, Zhu W, Liu C, Weng S, Wu H, Sun Y, Zhang R, Wu L, Li M, Zhu J, Zhang Y, Wei M, Guo Y, Huang S, Zhang N, Shen R, Zhang Y, Du H, Huang H, He L, Sun X, Shen L, Qin S. Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes, Molecular Psychiatry, 2022, 27: 5195-5205

3. Wu X# , Huai C #, Shen L, Li M, Yang C, Zhang J, Chen L, Zhu W, Fan L, Zhou W, Xing Q, He L*, Wan C, Qin S*. Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios, ISCIENCE, 2021, 24(8)
      4.Huai C, Wei Y, Li M, Zhang X, Wu H, Qiu X, Shen L, Chen L, Zhou W, Zhang N, Zhu G, Zhang Y, Zhang Z, He L, Qin S*. Genome-Wide Analysis of DNA Methylation and Antituberculosis Drug-Induced Liver Injury in the Han Chinese Population[J]. Clinical Pharmacology & Therapeutics, 2019, 106(6): 1389-1397.

5.Huai C#, Li G#, Yao R#, Zhang Y, Cao M, Kong L, Jia C, Yuan H, Chen H, Lu D*, Huang Q*. Structural insights into DNA cleavage activation of CRISPR-Cas9 system[J]. Nature Communications, 2017, 8.

6.Huai C#, Jia C#, Sun R, Xu P, Min T, Wang Q, Zheng C, Chen H*, Lu D*. CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice[J]. Human Genetics, 2017, 136(7): 875-883.

7. Wei Y#, Huai C#, Zhou C#, Gao Y, Chen L, Zhou W, Wei M, Qin S*. A methylation functional detection hepatic cell system validates correlation between DNA methylation and drug-induced liver injury[J]. Pharmacogenomics Journal, 2020.

8. Jia C#, Huai C#, Ding J, Hu L, Su B, Chen H*, Lu D*. New applications of CRISPR/Cas9 system on mutant DNA detection[J]. Gene, 2018, 641: 55-62.

9. Huai C#, Song J, Ma Z, Qin X, Li P, Chen H, Zhao F, Lu D, Song D, Mao Y, Song X*, Zhao Y*. Allelic Variation of the MMP3 Promoter Affects Transcription Activity through the Transcription Factor C-MYB in Human Brain Arteriovenous Malformations[J]. Plos One, 2013, 8(3).

10.Li M, Shen L, Chen L, Huai C, Huang H, Wu X, Yang C, Ma J, Zhou W, Du H, Fan L, He L*, Wan C*, Qin S*. Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients[J]. Translational Psychiatry, 2020, 10(1).

11.Sun Y, Zhou W, Chen L, Huai C, Huang H, He L, Qin S*. Omics in schizophrenia: current progress and future directions of antipsychotic treatments[J]. Journal of Bio-X Research, 2019, 2(4): 145-152.

12.Zhou W, Shi Y, Li F, Wu X, Huai C, Shen L, Yi Z, He L, Liu C, Qin S*. Study of the association between Schizophrenia and microduplication at the 16p11.2 locus in the Han Chinese population[J]. Psychiatry Research, 2018, 265: 198-199.

13.Song X, Zhou K, Zhao Y, Huai C, Zhao Y, Yu H, Chen Y, Chen G, Chen H, Fan W, Mao Y*, Lu D*. Fine mapping analysis of a region of 20q13.33 identified five independent susceptibility loci for glioma in a Chinese Han population[J]. Carcinogenesis, 2012, 33(5): 1065-1071.

14.周翔达, 宋晓, 怀聪, 孙海燕, 陈红岩, 卢大儒*. 耐热DNA连接酶介导的TLCR技术在简化DNA重组实验中的应用. 遗传, 2016, 38(2):163-169.（技术开发）

15.皮妍, 李晓莹, 怀聪, 王诗铭, 乔守怡*, 卢大儒*. 以人类血型为遗传学案例教学的思考与实践. 遗传, 2013. 35(8): 1040-1044. （教法论文）

16. Qin S., Ma J., Huai C., Zhou W. Pharmacogenomics of Psychiatric Drugs[B]. In: Cai W., Liu Z., Miao L., Xiang X. (eds) Pharmacogenomics in Precision Medicine. Springer, Singapore. (2020) https://doi.org/10.1007/978-981-15-3895-7_6 （Book Chapter）

# 并列第一作者， * 通讯作者