1. 利用冷冻电镜解析细胞表面受体蛋白复杂复合物的结构

2. 探索膜蛋白相关的肿瘤、代谢、神经等相关疾病的致病机理和治疗方法

3. 基于受体结构的药物分子设计

1.    Hao Zuo¹, Jinseo Park¹, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J. Manning, Wesley B. Asher, Zhengyuan Lu, Guobin  Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grasucci, Wayne A. Hendrickson, Oliver B. Clarke, Jonathan A. Javitch, Arthur D. Conigrave, Qing R. Fan: Promiscuous G-protein activation by the calcium-sensing receptor. Nature (2024) 629(8011):481-488.

2.    Hao Zuo, Yihong Wan: Inhibition of myeloid PD-L1 suppresses osteoclastogenesis and cancer bone metastasis. Cancer Gene Therapy (2022) 29(10):1342-1354.

3.    Jinseo Park¹, Hao Zuo¹, Aurel Frangaj¹, Ziao Fu¹, Laura Y. Yen¹, Zhening Zhang¹, Lidia Mosyak, Vesna N. Slavkovich, Jonathan Liu, Kimberly M. Ray, Baohua Cao, Francesca Vallese, Yong Geng, Shaoxia Chen, Robert Grassucci, Venkata P. Dandey, Yong Zi Tan,  Edward Eng, Yeji Lee, Brian Kloss, Zheng Liu, Wayne A. Hendrickson, Clinton S. Potter,  Bridget Carragher, Joseph Graziano, Arthur D. Conigrave, Joachim Frank,  Oliver B. Clarke, and  Qing R. Fan: Symmetric activation and modulation of the human calcium-sensing receptor. Proc. Natl. Acad. Sci. USA. (2021) 118 (51) e2115849118.

4.    Hao Zuo¹, Dengbao Yang¹, Yihong Wan: Fam20C regulates bone resorption and breast cancer bone metastasis through osteopontin and BMP4. Cancer Research (2021) 81 (20), 5242-5254.

5.    Hao Zuo, Dengbao Yang, Qiwen Yang, Haidong Tang, Yang-Xin Fu, Yihong Wan: Differential Regulation of Breast Cancer Bone Metastasis by PARP1 and PARP2. Nature Communications (2020) 11, 1578.

6.    Hao Zuo¹, Ian Glaaser¹, Yulin Zhao¹, Igor Kurinov¹, Lidia Mosyak¹, Haonan Wang¹, Jonathan Liu¹, Jinseo Park, Aurel Frangaj, Emmanuel Sturchler, Ming Zhou, Patricia McDonald, Yong Geng, Paul Slesinger, Qing Fan: Structural basis for auxiliary subunit KCTD16 regulation of the GABA_B receptor. Proc. Natl. Acad. Sci. USA. (2019) 116(17), 8370-‌8379.

7.    Hao Zuo and Yung H. Wong: Association of activated Gα_q to the tumor suppressor Fhit is enhanced by phospholipase Cβ. BMC Cancer (2015) 15:775.

8.    Hao Zuo, Anthony S.L. Chan, Hermann Ammer, and Yung H. Wong: Activation of Gα_q subunit up-regulates the expression of the tumor suppressor Fhit. Cellular Signalling (2013) 25:2440–2452.

9.    Hao Zuo, Grace P.W. Chan, Jing Zhu, Wendy W. S. Yeung, Anthony S.L. Chan, Hermann Ammer, and Yung H. Wong: Activation state-dependent interaction between Gα_q subunits and the Fhit tumor suppressor. Cell Communication and Signaling (2013) 11:59.

10.  Hao Zuo, Yihong Wan: Metabolic Reprogramming in Mitochondria of Myeloid Cells. Cells (2020) 9(1), 5.

11.  Hao Zuo, Yihong Wan: Nuclear Receptors in Skeletal Homeostasis. Curr. Top. Dev. Biol. (2017) 125:71-107.  

12.  Jinseo Park, Ziao Fu, Aurel Frangaj, Jonathan Liu, Lidia Mosyak, Tong Shen, Vesna N Slavkovich, Kimberly M Ray, Jaume Taura, Baohua Cao, Yong Geng, Hao Zuo, Yongjun Kou, Robert Grassucci, Shaoxia Chen, Zheng Liu, Xin Lin, Justin P Williams, William J Rice, Edward T Eng, Rick K Huang, Rajesh K Soni, Brian Kloss, Zhiheng Yu, Jonathan A Javitch, Wayne A Hendrickson, Paul A Slesinger, Matthias Quick, Joseph Graziano, Hongtao Yu, Oliver Fiehn, Oliver B Clarke, Joachim Frank, Qing R Fan: Structure of human GABA B receptor in an inactive state. Nature (2020) 584, 304–309.

13.  Shwu-Yuan Wu, Chien-Fei Lee, Hsien-Tsung Lai, Cheng-Tai Yu, Ji-Eun Lee, Hao Zuo, Sophia Y Tsai, Ming-Jer Tsai, Kai Ge, Yihong Wan, Cheng-Ming Chiang: Opposing Functions of BRD4 Isoforms in Breast Cancer. Molecular Cell (2020) 78(6):1114-1132.e10.

14.  Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Yihong Wan, and Daniel J. Siegwart: High Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size Controlled pH-activatable Water Soluble Probes. Advanced Materials (2017) 29, 1700131.

15.  Peiwen Chen, Hao Zuo, Hu Xiong, Matthew J. Kolar, Qian Chu, Alan Saghatelian, Daniel J. Siegwart and Yihong Wan: Gpr132 Sensing of Lactate Mediates Tumor-Macrophage Interplay to Promote Breast Cancer Metastasis. Proc. Natl. Acad. Sci. USA. (2017) 114(3):580-585.

16.  Xiaoxiao Li, HoangDinh Huynh, Hao Zuo, Marjo Salminen, and Yihong Wan: Gata2 Is a Rheostat for Mesenchymal Stem Cell Fate in Male Mice. Endocrinology (2016) 157(3):1021-8.

17.  Yong Geng, Lidia Mosyak, Igor Kurinov, Hao Zuo, Emmanuel Sturchler, Tat Cheung Cheng, Prakash Subramanyam, Alice P Brown, Sarah C Brennan, Hee-chang Mun, Martin Bush, Yan Chen, Trang X Nguyen, Baohua Cao, Donald D Chang, Matthias Quick, Arthur D Conigrave, Henry M Colecraft, Patricia McDonald, and Qing R Fan: Structural mechanism of ligand activation in human calcium-sensing receptor. eLife (2016) 5:e13662.

18.  Xiaoxiao Li, Wei Wei, HoangDinh Huynh, Hao Zuo, Xueqian Wang, and Yihong Wan: Nur77 prevents excessive osteoclastogenesis by inducing ubiquitin ligase Cbl-b to mediate NFATc1 self-limitation. eLife (2015) 4:e07217.