2005年获美国ASBMR学会杰出青年科学家奖，2005年获美国国立卫生研究院优秀博士后研究奖，2007 国家重大科学研究计划“骨骼发育与相关疾病的分子机理研究”项目首席科学家。2008年上海“浦江人才”计划获得者。

骨关节炎和骨质疏松的分子遗传学分析；骨骼间充质干细胞分化，衰老和代谢的调控；骨骼与脂肪代谢的相互作用研究。

1. Haixia Zhao, Wenrong Zhou, Zhengju Yao, Yong Wan, Jingjing Cao, Lingling Zhang, Jianzhi Zhao, Hanjun Li, Rujiang Zhou, Baojie Li, Gang Wei, Zhenlin Zhang, Catherine A. French, Joseph D. Dekker, Yingzi Yang, Simon E. Fisher, Haley O. Tucker, Xizhi Guo* (2015) Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Developmental Biology398:242-254.

2. Lingling  Zhang; Hanjun Li; Jian  Yu; Jingjing  Cao; Huihui Chen; Haixia  Zhao; Jianzhi  Zhao; Yiyun Yao; Lifang  Wang; Rujiang  Zhou; Zhengju  Yao, Xizhi Guo* (2014) Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Developmental Biology 387: 64–72

3. Xuming Zhu, Sixia Huang, Lingling Zhang, Yumei Wu, Yingwei Chen, Yixin Tao, Yushu Wang, Shigang He, Sanbing Shen, Ji Wu, Baojie Li, Xizhi Guo*, Lin He*, Gang Ma* (2014) Constitutive Activation of Ectodermal β-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure. Plos One 9(3): e92092

4. Wenrong Zhou, Huang Zhu, Jinazhi Zhao, Hanjun Li, Yong Wan, Jingjing Cao, Haixia Zhao, Jian Yu, Rujiang Zhou, Yiyun Yao, Lingling Zhang, Lifang Wang, Lin He, Gang Ma, Zhengju Yao, Xizhi Guo* (2013) Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation. PLoS One. 8(5):e64237

5. Yong Wan，Cheng Lu, Jingjing Cao, Rujiang Zhou, Yiyun Yao,Jian Yu,Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Xuming Zhu, Lin He, Yongzhong Liu, Zhengju Yao, Xiao Yang and Xizhi Guo* (2013) Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells. Bone. 55(1):258-67

6. Cheng Lu, Yong Wan, Jingjing Cao,Xuming Zhu, Jian Yu,Rujiang Zhou, Yiyun Yao, Lingling Zhang, Haixia Zhao, Hanjun Li, Jianzhi Zhao, Lin He, Gang Ma, Zhengju Yao, and Xizhi Guo*(2013) Wnts-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 53(2):566-74.

7. Huang Zhu, Jianzhi Zhao, Wenrong Zhou, Hanjun Li, Rujiang Zhou, Lingling Zhang, Haixia Zhao, Jingjing Cao, Xuming Zhu, Hongliang Hu, Gang Ma, Lin He, Zhengju Yao, Libo Yao, Xizhi Guo* (2012) Ndrg2 regulates vertebral specification in differentiating somites. Developmental Biology. 369(2):308-18.

8. Xuming Zhu, Huang Zhu, Lingling Zhang, Sixia Huang, Jingjing Cao, Gang Ma, Guoying Feng, Lin He, Yingzi Yang, Xizhi Guo* (2012) Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis. Developmental Biology. 365(2):328-38.

9. Sixia Huang, Xuming Zhu, Yanfang Liu, Yixin Tao, Guoyin Feng, Lin He, Xizhi Guo*, Gang Ma (2012) Wls Is Expressed in the Epidermis and Regulates Embryonic Hair Follicle Induction in Mice. PLoS One. 7(9):e45904.

10. Yang J, Qin S, Yi C, Ma G, Zhu H, Zhou W, Xiong Y, Zhu X, Wang Y, He L, Guo X*. MiR-140 is co-expressed with Wwp2-C transcript and activated by Sox9 to target Sp1 in maintaining the chondrocyte proliferation. FEBS Lett. 2011;585(19):2992-7.

11. Xiao Y, Zhang L, He K, Gao X, Yang L, He L, Ma G, Guo X*. Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis. J Genet Genomics. 2011; 38(8):333-9.

12. Guo X, Mak KK, Taketo MM, Yang Y*. The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 2009; 26;4(6):e6067.

13. Lin C#, Jiang X#, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X*, He L*. Sclerostin Mediates Bone Response to Mechanical Unloading via Antagonizing Wnt/beta-Catenin Signaling. J Bone Miner Res. 2009; 24(10):1651-61.

14. Zhou J, Meng J, Guo S, Gao B, Ma G, Zhu X, Hu J, Xiao Y, Lin C, Wang H, Ding L, Feng G, Guo X, He L*. IHH and FGF8 coregulate elongation of digit primordia. Biochem Biophys Res Commun. 2007; 363(3):513-8.

15. Day TF#, Guo X#, Garrett-Beal L, Yang Y*. Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell. 2005; 8 (5): 739-750.

16. Guo X#, Day TF#, Jiang X, Garrett-Beal L, Topol L, Yang Y*. Wnt/-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev. 2004; 18:2404-2417.

#并列第一作者 *通讯作者

上海交通大学Bio-X研究院副研究员。武汉大学学士，浙江大学硕士，中国科学院上海生物化学与细胞生物学研究所博士，美国德州大学圣安东尼健康中心和弗罗里达大学博士后。

骨质疏松的基础及临床前研究。 成体间充质细胞趋成骨细胞的分化特性研究。

1. Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A. 2012, 109(9): 3359-64.

2. Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest. 2012, 122(7): 2543-53.

3. Aguirre JI, Akhter MP, Kimmel DB, Pingel J, Xia X, Williams A, Jorgensen M, Edmonds K, Lee JY, Reinhard MK, Battles AH, Kesavalu L, Wronski TJ. Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats. Oral Dis. 2012, 18(5): 459-68.

4. Halloran BP, Wronski TJ, Herzen DV, Chu V, Xia X, Pingel JE, Smith B. Dietary dried plum increases bone mass in adult and aged mice. Journal of Nutrition, 2010, 140(10): 1781-1787.

5. Xia X, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald LF, Biswas SK, Lo WK, Jiang JX. Glucocorticoid induced autophagy in osteocytes. Journal of Bone and Mineral Research, 2010, 25(11): 2479–2488.

6. Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX. Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Molecular and Cellular Biology, 2010, 30(1): 206-219.

7. Xia X, Hou F, Li J, Ke Y, Nie H. Two novel proteins bind specifically to trichosanthin on choriocarcinoma cell membrane. Journal of Biochemistry, 2006, 139: 725-731.

8. Xia X, Hou F, Li J, Nie H. Ribosomal protein L10a, a bridge between trichosanthin and the ribosome. Biochemical and Biophysical Research Communications, 2005, 336: 281-286.

#并列第一作者 *通讯作者