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郭熙志

博士, 特聘教授,课题组长,博导

学    士 (1993-1997) 武汉大学
博    士 (1997-2002) 中科院上海植物生理生态所
博士后 (2003-2007) 美国NIH人类基因组研究所
教    授(2007-)上海交通大学Bio-X研究院

Email:xzguo2005@sjtu.edu.cn

个人介绍

2005年获美国ASBMR学会杰出青年科学家奖,2005年获美国国立卫生研究院优秀博士后研究奖,2007 国家重大科学研究计划“骨骼发育与相关疾病的分子机理研究”项目首席科学家。2008年上海“浦江人才”计划获得者等等。先后负责承担多项科技部与自然基金委研究项目,在Genome Biology, Journal of Clinical Investigation, PNAS, Nature Communications等国际一流科学期刊, 以通讯作者发表研究成果,获批发明专利7项。


      

研究方向

代谢疾病的基因治疗开发:

  • 骨关节炎,糖尿病等退行性疾病的分子机制研究,
  • 多肽与环形RNA等创新药物治疗代谢疾病

代表性论文

1. Shifeng Ling, Tienan Chen, Shaojiao Wang, Wei Zhang, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Song Ning, Jiayin Liu, Lianju Qin, Haley O. Tucker, Niansong Wang*, Xizhi Guo*(2023). Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells. Stem Cell Research&Therapy. 14:188

2. Fuhua Wang, Shuqin Xu, Tienan Chen, Shifeng Ling, Wei Zhang, Shaojiao Wang, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Pengxiao Li, Xiaodong Zhao, Jiqiu Wang, Xizhi Guo* (2022). FOXP4 differentially controls cold-induced beige adipocyte differentiation and thermogenesis. Development.149(7): dev200260.

3. Pei Liu, Sixia Huang, Shifeng Ling, Fuhua Wang, Wei Zhang, Shuqin Xu, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu Wang*, Xizhi Guo* (2019). Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating b3-AR desensitization. Nature Communications. 10: 5070.

4. Shuqin Xu, Pei Liu, Yuanxin Chen, Yi Chen, Wei Zhang, Haixia Zhao, Yiwei Cao, Fuhua Wang, Nana Jiang, Shifeng Lin, Baojie Li, Zhenlin Zhang, Zhanying Wei, Ying Fan, Yunyun Jin, Lin He, Rujiang Zhou, Joseph D. Dekker, Haley O. Tucker, Simon E. Fisher, Zhengju Yao, Quansheng Liu*, Xuechun Xia*, Xizhi Guo* (2018). Foxp2 regulates anatomical features that may be relevant for vocal behavior and bipedal locomotion. PNAS. Aug 28;115(35): 8799-8804.

5. Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D. Dekker, Baojie Li, Zhenlin Zhang, Yang Hong, Gong Yang, Tingting Tang, Yongxin Ren, Haley O. Tucker, Zhengju Yao, Xizhi Guo*. Foxp1 controls cell fate commitment and senescence of mesenchymal stem cells during skeletal aging (2017). Journal of Clinical Investigation. 127(4):1241-1253.

 *通讯作者