郭熙志
博士, 特聘教授，2007重大科学研究计划首席科学家，课题组长，博导
学 士 (1993-1997) 武汉大学
博 士 (1997-2002) 中科院上海植物生理生态所
博士后 (2003-2007) 美国NIH人类基因组研究所
教 授（2007-）上海交通大学Bio-X研究院
Email：xzguo2005@sjtu.edu.cn
博士, 特聘教授，2007重大科学研究计划首席科学家，课题组长，博导
学 士 (1993-1997) 武汉大学
博 士 (1997-2002) 中科院上海植物生理生态所
博士后 (2003-2007) 美国NIH人类基因组研究所
教 授（2007-）上海交通大学Bio-X研究院
Email：xzguo2005@sjtu.edu.cn
2005年获美国ASBMR学会杰出青年科学家奖，2005年获美国国立卫生研究院优秀博士后研究奖，
2007 国家重大科学研究计划“骨骼发育与相关疾病的分子机理研究”项目首席科学家。
2008年上海“浦江人才”计划获得者。
2021年中组部中青年科技创新领军人才“万人计划”获得者。
骨质疏松与骨关节炎疾病机理研究；
脂肪代谢调控与糖尿病治疗
代谢疾病的基因治疗方法开发
1. Shifeng Ling, Tienan Chen, Shaojiao
Wang, Wei Zhang, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Song Ning,
Jiayin Liu, Lianju Qin, Haley O. Tucker, Niansong Wang*, Xizhi Guo*(2023).
Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem
cells. Stem Cell Research&Therapy. 14:188
2. Fuhua Wang, Shuqin Xu, Tienan Chen,
Shifeng Ling, Wei Zhang, Shaojiao Wang, Rujiang Zhou, Xuechun Xia, Zhengju Yao,
Pengxiao Li, Xiaodong Zhao, Jiqiu Wang, Xizhi Guo* (2022). FOXP4 differentially
controls cold-induced beige adipocyte differentiation and thermogenesis. Development.149(7):
dev200260.
3. Pei Liu, Sixia Huang, Shifeng Ling,
Fuhua Wang, Wei Zhang, Shuqin Xu, Rujiang Zhou, Lin He, Xuechun Xia, Zhengju
Yao, Ying Fan, Niansong Wang, Congxia Hu, Xiaodong Zhao, Haley O. Tucker, Jiqiu
Wang*, Xizhi Guo* (2019). Foxp1 controls brown/beige adipocyte
differentiation and thermogenesis through regulating b3-AR desensitization. Nature
Communications. 10: 5070.
4. Shuqin Xu, Pei Liu, Yuanxin Chen, Yi
Chen, Wei Zhang, Haixia Zhao, Yiwei Cao, Fuhua Wang, Nana Jiang, Shifeng Lin,
Baojie Li, Zhenlin Zhang, Zhanying Wei, Ying Fan, Yunyun Jin, Lin He, Rujiang
Zhou, Joseph D. Dekker, Haley O. Tucker, Simon E. Fisher, Zhengju Yao,
Quansheng Liu*, Xuechun Xia*, Xizhi Guo* (2018). Foxp2 regulates anatomical
features that may be relevant for vocal behavior and bipedal locomotion. PNAS.
Aug 28;115(35): 8799-8804.
5. Hanjun Li, Pei Liu, Shuqin Xu, Yinghua
Li, Joseph D. Dekker, Baojie Li, Zhenlin Zhang, Yang Hong, Gong Yang, Tingting
Tang, Yongxin Ren, Haley O. Tucker, Zhengju Yao, Xizhi Guo*. Foxp1
controls cell fate commitment and senescence of mesenchymal stem cells during
skeletal aging (2017). Journal of Clinical Investigation. 127(4):1241-1253.
*通讯作者
博士, 副研究员, 硕导
学 士 (1991-1995) 武汉大学
硕 士 (1998-2001) 浙江大学
博 士 (2001-2006) 中科院上海生化所
博士后 (2006-2008) 美国德州大学圣安东尼健康中心
博士后 (2008-2011) 弗罗里达大学
Email：xuechun.xia@sjtu.edu.cn
上海交通大学Bio-X研究院副研究员。武汉大学学士，浙江大学硕士，中国科学院上海生物化学与细胞生物学研究所博士，美国德州大学圣安东尼健康中心和弗罗里达大学博士后。
骨质疏松的基础及临床前研究。 成体间充质细胞趋成骨细胞的分化特性研究。
1. Batra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels. Proc Natl Acad Sci U S A. 2012, 109(9): 3359-64.
2. Shalhoub V, Shatzen EM, Ward SC, Davis J, Stevens J, Bi V, Renshaw L, Hawkins N, Wang W, Chen C, Tsai MM, Cattley RC, Wronski TJ, Xia X, Li X, Henley C, Eschenberg M, Richards WG. FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest. 2012, 122(7): 2543-53.
3. Aguirre JI, Akhter MP, Kimmel DB, Pingel J, Xia X, Williams A, Jorgensen M, Edmonds K, Lee JY, Reinhard MK, Battles AH, Kesavalu L, Wronski TJ. Enhanced alveolar bone loss in a model of non-invasive periodontitis in rice rats. Oral Dis. 2012, 18(5): 459-68.
4. Halloran BP, Wronski TJ, Herzen DV, Chu V, Xia X, Pingel JE, Smith B. Dietary dried plum increases bone mass in adult and aged mice. Journal of Nutrition, 2010, 140(10): 1781-1787.
5. Xia X, Kar R, Gluhak-Heinrich J, Yao W, Lane NE, Bonewald LF, Biswas SK, Lo WK, Jiang JX. Glucocorticoid induced autophagy in osteocytes. Journal of Bone and Mineral Research, 2010, 25(11): 2479–2488.
6. Xia X, Batra N, Shi Q, Bonewald LF, Sprague E, Jiang JX. Prostaglandin promotion of osteocyte gap junction function through transcriptional regulation of connexin 43 by glycogen synthase kinase 3/beta-catenin signaling. Molecular and Cellular Biology, 2010, 30(1): 206-219.
7. Xia X, Hou F, Li J, Ke Y, Nie H. Two novel proteins bind specifically to trichosanthin on choriocarcinoma cell membrane. Journal of Biochemistry, 2006, 139: 725-731.
8. Xia X, Hou F, Li J, Nie H. Ribosomal protein L10a, a bridge between trichosanthin and the ribosome. Biochemical and Biophysical Research Communications, 2005, 336: 281-286.
#并列第一作者 *通讯作者