1999-2004年美国犹他大学Research Fellow、美国天普大学Associate Scientist。获2020年国家自然科学二等奖 (排名1), 入选中国高等学校十大科技进展, 获上海市自然科学一等奖 (排名1)。曾主持国家自然科学基金重点和重点国合项目等。任美国RB&E杂志Section Editor与数家国际杂志编委，上海市生理科学会理事，中国生殖生物学会理事。发表SCI论文100余篇。获欧洲、美国及中国授权专利。

生殖发育与表观遗传学

干细胞生物学

1. Luo Y, Yin M, Mu C, Hu X, Xie H, Li J, Cao T, Chen N*, Wu J*. Fan C*. Engineering female germline stem cells with exocytotic polymer dots. Advanced Materials. 2023; 35: e2210458.

2. Fang Q, Tian G G, Wang Q, Liu M, He L*, Li S*, Wu J*. Ythdf1 phase separation triggers the fate transition of spermatogonial stem cells by activating the ikappab-nf-kappab-ccnd1 axis. Cell Reports. 2023; 42: 112403.

3. Tian GG#, Hou C#, Li J*, Wu J*. Three‐dimensional genome structure shapes the recombination landscape of chromatin features during female germline stem cell development. Clinical and translational medicine. 2022; 12: e927.

4. Hou C, Zhao X, Tian GG*, Wu J*. Stella Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation. International Journal of Biological Sciences. 2022; 18: 3006.

5. Li X, Zheng M, Xu B, Li D, Shen Y, Nie Y, Ma L*, Wu J*. Generation of offspring-producing 3D ovarian organoids derived from female germline stem cells and their application in toxicological detection. Biomaterials. 2021; 279: 121213.

6. Zhang X-L#, Wu J#, Wang J#, Shen T, Li H, Lu J, Gu Y, Kang Y, Wong C-H, Ngan CY, Shao Z, Wu J* and Zhao X*. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biology. 2016; 17: 1-12.

7. Wu C, Xu B, Li X, Ma W, Zhang P, Chen X, Wu J*. Tracing and characterizing the development of transplanted female germline stem cells in vivo. Molecular Therapy. 2017; 25: 1408-1419.

8. Zou K, Yuan Z, Yang Z, Luo H, Sun K, Zhou L, Xiang J, Shi L, Yu Q, Zhang Y, Hou R, Wu J*. Production of offspring from a germline stem cell line derived from neonatal ovaries. Nature Cell Biology. 2009; 11: 631-636.

#并列第一作者 *通讯作者

主持国家自然科学基金青年科学项目，上海市自然科学基金面上项目等。参与国家重点科学研究计划项目，国家自然科学基金国际（地区）合作与交流项目等。

生殖生理

1. Liu M, Wang S, Gao W, Zhang J, Zhang B, Rodgers RJ, Tian GG*, Li X*, Wu J*. Polystyrene nanoplastics disrupt ovarian development via cytoskeletal remodeling and epigenetic reprogramming particularly in granulosa cells. J Hazard Mater. 2026 Mar 1;505:141467. 

2.  Mu C#,Li X#*, Yang J, Tian GG, Bai H, Lin W*, Wang L*, Wu J*. Spatial Transcriptome and Single Nucleus Transcriptome Sequencing Reveals Tetrahydroxy Stilbene Glucoside Promotes Ovarian Organoids Development Through the Vegfa-Ephb2 Pair. Adv Sci (Weinh). 2025 Jan;12(4):e2410098.

3.  Wang X, Tian GG, Cheng W*, Yu X*, Li X*, Wu J*. Metformin promotes female germline stem cell proliferation by upregulating Gata-binding protein 2 with histone β-hydroxybutyrylation. Stem Cell Res Ther. 2023 May 26; 14(1):144.

4.  Nie Y, Xu W, Tian GG, Li X, Guo Y, Liu X, He L, Shao Z, Li X*, Wu J*. Mechanistic insights into HuR inhibitor MS-444 arresting embryonic development revealed by low-input RNA-seq and STORM. Cell Biol Toxicol. 2022 Dec; 38(6):1175-1197.

5.  Li X,Yao X, Mu C, Wang Z, Hu R*, Chang Y*, Wu J*. Serum- and Feeder-Free Culture of Juvenile Monkey Female Germline Stem Cells and Testosterone Regulation of their Self-Renewal. Stem Cell Rev Rep. 2022 Jan; 18(1):336-345. 

6.  Li X, Zheng M, Xu B, Li D, Shen Y, Nie Y, Ma L*, Wu J*. Generation of offspring-producing 3D ovarian organoids derived from female germline stem cells and their application in toxicological detection. Biomaterials. 2021 Dec; 279:121213.

7.  Wang Y#, Li X#, Gong X, Zhao Y, Wu J*. MicroRNA-322 Regulates Self-renewal of Mouse Spermatogonial Stem Cells through Rassf8. Int J Biol Sci. 2019 Mar 1; 15(4):857-869. 

#并列第一作者 *通讯作者

[1] Xinyue Li, Xiaopeng Hu#(共同通讯作者), Ji Wu#. “N4-acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1.” Advanced Science 2026(0):e20059. (IF 14.1)

[2] Yabin Zhang, Geng G. Tian, Xiang Wang, Changliang Hou, Xiaopeng Hu#( 共同通讯作者), Ji Wu#(2022). "Retinoic acid induced meiosis initiation in female germline stem cells by remodelling three-dimensional chromatin structure." Cell Proliferation 55(7):e13242. (IF 5.6)

[3] Xiaopeng Hu*(第一作者), Hu Wang*, Geng. G. Tian*, Changliang Hou*,Bo Xu, Xinyan Zhao, Yongqiang Zhao, Qian Fang, Xinyue Li, Lin He, Xuejin Chen, Shangang Li# and Ji Wu# (2022). "Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation."Cell and Bioscience 12(1):5. (IF 6.2)

[4] Xiaoyan Yuan*, Geng.G Tian *, Xiuying Pei, Xiaopeng Hu#(共同通讯作者), Ji Wu#. (2021). "Spermidine induces cytoprotective autophagy of female germline stem cells in vitro and ameliorates aging caused by oxidative stress through upregulated Sequestosome-1/p62 expression." Cell and Bioscience 11(1):107. (IF 6.2)

[5] Bo Li*, Xiaopeng Hu*(共同第一作者), Yanzhou Yang, Mingyan Zhu, Jiong Zhang, Yanrong Wang, Xiuying Pei, Huchen Zhou# and Ji Wu#. (2019). "GAS5/miR-21 axis as a potential target to rescue ZCL-082-induced autophagy of female germline gtem gells in vitro" Molecular Therapy-Nucleic Acids 17: 436-447. (IF 6.1)

[6] Xiaopeng Hu*(第一作者), Junping Ao*, Xinyue Li, Huijuan Zhang, Ji Wu #and Weiwei Cheng#(2018). "Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia." Clinical Epigenetics 10:48. (IF 4.4)

[7] Xiaopeng Hu*(第一作者)，Jiahua Cui*，Jun Chen*，Shujuan Du，XinyuWang，YabinZhang，JiajunQian，HaifengChen，FangWei#，QiliangCai#， JinpingJia#，JiWu# (2022). "Identification of hACE2-interacting sites in SARS-CoV-2 spike receptor binding domain for antiviral drugs screening." Virus Research321:198915. (IF 2.7)

[8] Xinyue Li*, Xiaopeng Hu*( 共同第一作者), Geng Tian*, Ping Chen, Zezhong Li, Mingyan Zhu, Huchen Zhou#, Ji Wu# (2019). "C89 induces autophagy of female germline stem cells via inhibition of the PI3K-Akt pathway in vitro." Cells 8(6):606. (IF 5.2)

[9] Fangfang Li, Xiaopeng Hu#(共同通讯作者), Ji Wu# (2022). "Daidzein activates Akt pathway to promote the proliferation of female germline stem cells through upregulating Clec11a." Stem Cell Reviews and Reports 18(8): 3021-3032. (IF 4.2)

[10] Lu Wang, Xiaopeng Hu#(共同通讯作者), Ji Wu# (2024). "STING signaling contributes to celastrol-induced pyroptosis of female germline stem cells by upregulating NLRP3." Stem Cell Reviews and Reports 20(2): 573-575. (IF 4.2)

[11] Wenjie Liu, Zhaokai Wang# and Xiaopeng Hu#(主要通讯作者) (2021)."Identification of competing endogenous RNA and micro-RNA profiles and regulatory networks in 4-Nonylphenol-induced impairment of Sertoli cells." Frontiers in Pharmacology 12:644204. (IF 4.8)

[12] Zhaojuan Yang*, Bo Xu*, Xiaopeng Hu*(共同第一作者), Shuzeng Wang, Haifeng Chen and Ji Wu#(2019). "Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3." Journal of Cellular and Molecular Medicine 23(1): 417-425. (IF 4.2)

[13] Xiaopeng Hu*(第一作者), Zhenzhou Tang*, Yang Li*, Wensheng Liu,Shuang Zhang, Bingyan Wang, Yingpu Tian, Yinan Zhao, Hao Ran, Wenjie Liu, Gen-Sheng Feng, Jianwei Shuai, Haibin Wang#, and Zhongxian Lu# (2015). "Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice." Scientific Reports 5:12982. (IF 3.9)

[14] Jiang Li*，Xiang Liu*，Xiaopeng Hu*(共同第一作者)，Geng G. Tian， Wenzhi Ma，Xiuying Pei#，Yanrong Wang#，Ji Wu#(2017). "MicroRNA-10b regulates the renewal of spermatogonial stem cells through Kruppel-like factor 4." Cell Biochemistry and Function 35(3): 184-191. (IF 2.7)