上海交大Bio-X研究院个体化医学研究中心主任（与哈佛-麻省理工 Broad研究所共建），上海交大个体化医学交叉学科创新人才实践培养基地主任，上海浦江人才。现为我国药物基因组学专委会副主任委员、常委，我国个体化用药科技创新联盟副秘书长，上海浦东新区转化医学联盟副秘书长，国家卫计委项目临床遗传专科委员会委员。曾先后担任国际学术期刊共同主编、编委、SCI期刊（Frontiers in Pharmacology）副主编；发表学术论文100余篇，申请专利 33项，已授权12项, 其中3项获转让，主编及参编著作6部，主持及参与制定指南与标准4项。主持国家863计划重大项目、国家自然基金、国家新药创制重大专项子课题、上海科技创新行动计划等项目。曾获国际人类遗传学会议青年研究者奖、全国高校生物类微课竞赛二等奖等。

药物基因组学与个体化医学；出生缺陷及疾病基因组学

研究并发现精神神经疾病、心脑血管疾病、肿瘤、严重药物不良反应、重大出生缺陷等一系列个体化医学相关分子标记物，基于一系列功能研究技术手段探索不同个体对药物、环境等各类因子的反应存在差异的分子机制，研制个体化医学高通量快速检测技术手段及疾病个体化治疗方案，建立各相关疾病个体化精准医疗技术体系。

1.      Yunfeng Ruan, Yen-Feng Lin, Yen-Chen Anne Feng, Chia-Yen Chen, Max Lam, Zhenglin Guo, Stanley Global Asia Initiatives, Lin He, Akira Sawa, Alicia  R. Martin, Shengying Qin*, Hailiang Huang* and Tian Ge* Improving polygenic prediction in ancestrallly diverse populations. Nature Genetics,2022 May.

2.      Wei Zhou#, Jing Sun#, Cong Huai#, Yunxi Liu, Luan Chen, Zhenghui Yi, Qinyu Lv, Chuanfu Song, Wenli Zhu,Chuanxin Liu, Saizheng Weng, Hao Wu, Yidan Sun, Runshuai Zhang, Lianfeng Wu, Mo Li, Jinhang Zhu, Yingtian Zhang, Muyun Wei, Yujian Guo, Sijia Huang, Na Zhang, Ruoxi Shen, Ying Zhang, Huihui Du, Hailiang Huang, Lin He, Xiaofang Sun, Lu Shen, Shengying Qin*, Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes. Molecular Psychiatry, 2022 Sep. 05; doi.org/10.1038/s41380-022-01759-5

3.      Jing Sun; Xiaoya Zhang; Qijie Cong; Dong Chen; Zhenghui Y; Hailiang Huang; Cong Wang; Mo Li; Rongsen Zeng; Yunxi Liu; Cong Huai; Luan Chen; Chuanxin Liu; Yan Zhang; Yong Xu; Lingzi Fan; Guoqiang Wang; Chuanfu Song; Muyun Wei; Huihui Du; Jinhang Zhu; Lin He; Shengying Qin*, MiR143-3p-mediated neuregulin-1-dependent mitochondrial dysfunction contributes to olanzapine resistance in refractory schizophrenia, Biological Psychiatry, 2022 March.

4.      Lu Shen#, Xiaoying Lv#, Hailiang Huang, Mo Li, Cong Huai, Xi Wu, Hao Wu, Jingsong Ma, Luan Chen, Ting Wang, Jie Tan, Yidan Sun, Lixing Li, Yi Shi, Chao Yang, Lei Cai, Yana Lu, Yan Zhang, Saizheng Weng, Shaobin Tai, Na Zhang, Lin He*, Chunling Wan*, Shengying Qin*. Genome-wide analysis of DNA methylation in 106 schizophrenia family trios in Han Chinese. EBioMedicine, 2021 Oct 7;72:103609.

5.      Jingsong Ma#, Mingzhe Zhao#, Wei Zhou, Mo Li, Cong Huai, Lu Shen, Ting Wang, Hao Wu, Na Zhang, Zhiruo Zhang, Lin He, Shengying Qin*. Association between the COMT Val158Met polymorphism and antipsychotic efficacy in schizophrenia: an updated meta-analysis. Curr Neuropharmacol. 2020 Oct 23.

6.      Mo Li, Yongkun Chen, Tao Chen, Shixiong Hu, Luan Chen, Lu Shen, Fangcai Li, Jing Yang, Yan Sun, Dayan Wang, Lin He, Shengying Qin*, Yuelong Shu*. A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection. Emerging Microbes & Infections. 2020 Dec;10(1):123-131.

7.      Shaowei Mao, Di Zhang, Luan Chen, Jie Tan, Yunpeng Chu, Sijia Huang, Wenqi Zhou, Hengwei Qin, Qinghua Xia, Yueran Zhao, Rongxiu Li, Shengying Qin* & Muyun Wei*. FKBP51 promotes invasion and migration by increasing the autophagic degradation of TIMP3 in clear cell renal cell carcinoma. Cell Death & Disease 2021, 12(10).

8.      Gaoping Cui, Ying Qing, Xiaowen Hu, Pengkun Wang, Liya Sun, Xuhan Yang, Jie Jiang, Juan Zhang, Hang Wang, Lei Feng, Yuhua Shen, Shengying Qin*,Chunling Wan*. Serum Metabolomic Profiling Based on Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry: Do the Dysfunctions of Metabolic Pathways Reveal a Universal Risk of Oxidative Stress in Schizophrenia?. Antioxidants & Redox Signaling. 2020. 33(10): p. 679-688.

9.      Cong Huai, Yuqi Wei, Mo Li, Xiaoqing Zhang, Hao Wu, Xiaoyan Qiu, Lu Shen, Luan Chen, Wei Zhou, Na Zhang, Guanghui Zhu, Ying Zhang, Zhiruo Zhang, Lin He, Shengying Qin*. Genome-Wide Analysis of DNA Methylation and Antituberculosis Drug-Induced Liver Injury in the Han Chinese Population. Clin Pharmacol Ther. 2019 Dec;106(6):1389-1397.

10.    Max Lam#, Chia-Yen Chen#, …… Stephan Ripke, Michael C. O’Donovan, Mark J. Daly, Shengying Qin, et.al. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics, 2019 Dec;51(12):1670-1678. (co-supervise)

#并列第一作者 *通讯作者

中国药理学会药物基因组学专业委员会委员，上海市医学会医学遗传学分会青年委员。主持国家自然科学基金青年项目，上海市自然基金面上项目等。

关注药物反应的个体差异，应用多组学技术探索和开发严重药物不良反应的诊断及预警生物标志物。

1.药物不良反应相关分子标志物的探究

2.基于分子检测技术的DNA标志物检测技术的开发

1. Zhao M #, Ma J #, Li M #, Zhu W #, Zhou W, Shen L, Wu H, Zhang N, Wu S, Fu C, Li X, Yang K, Tang T, Shen R, He L, Huai C *, Qin S*. Different responses to risperidone treatment in Schizophrenia: a multicenter genome-wide association and whole exome sequencing joint study, Translational Psychiatry, 2022, 12(1)
      2.Zhou W #, Sun J #, Huai C #, Liu Y, Chen L, Yi Z, Lv Q, Song C, Zhu W, Liu C, Weng S, Wu H, Sun Y, Zhang R, Wu L, Li M, Zhu J, Zhang Y, Wei M, Guo Y, Huang S, Zhang N, Shen R, Zhang Y, Du H, Huang H, He L, Sun X, Shen L, Qin S. Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes, Molecular Psychiatry, 2022, 27: 5195-5205

3. Wu X# , Huai C #, Shen L, Li M, Yang C, Zhang J, Chen L, Zhu W, Fan L, Zhou W, Xing Q, He L*, Wan C, Qin S*. Genome-wide study of copy number variation implicates multiple novel loci for schizophrenia risk in Han Chinese family trios, ISCIENCE, 2021, 24(8)
      4.Huai C, Wei Y, Li M, Zhang X, Wu H, Qiu X, Shen L, Chen L, Zhou W, Zhang N, Zhu G, Zhang Y, Zhang Z, He L, Qin S*. Genome-Wide Analysis of DNA Methylation and Antituberculosis Drug-Induced Liver Injury in the Han Chinese Population[J]. Clinical Pharmacology & Therapeutics, 2019, 106(6): 1389-1397.

5.Huai C#, Li G#, Yao R#, Zhang Y, Cao M, Kong L, Jia C, Yuan H, Chen H, Lu D*, Huang Q*. Structural insights into DNA cleavage activation of CRISPR-Cas9 system[J]. Nature Communications, 2017, 8.

6.Huai C#, Jia C#, Sun R, Xu P, Min T, Wang Q, Zheng C, Chen H*, Lu D*. CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice[J]. Human Genetics, 2017, 136(7): 875-883.

7. Wei Y#, Huai C#, Zhou C#, Gao Y, Chen L, Zhou W, Wei M, Qin S*. A methylation functional detection hepatic cell system validates correlation between DNA methylation and drug-induced liver injury[J]. Pharmacogenomics Journal, 2020.

8. Jia C#, Huai C#, Ding J, Hu L, Su B, Chen H*, Lu D*. New applications of CRISPR/Cas9 system on mutant DNA detection[J]. Gene, 2018, 641: 55-62.

9. Huai C#, Song J, Ma Z, Qin X, Li P, Chen H, Zhao F, Lu D, Song D, Mao Y, Song X*, Zhao Y*. Allelic Variation of the MMP3 Promoter Affects Transcription Activity through the Transcription Factor C-MYB in Human Brain Arteriovenous Malformations[J]. Plos One, 2013, 8(3).

10.Li M, Shen L, Chen L, Huai C, Huang H, Wu X, Yang C, Ma J, Zhou W, Du H, Fan L, He L*, Wan C*, Qin S*. Novel genetic susceptibility loci identified by family based whole exome sequencing in Han Chinese schizophrenia patients[J]. Translational Psychiatry, 2020, 10(1).

11.Sun Y, Zhou W, Chen L, Huai C, Huang H, He L, Qin S*. Omics in schizophrenia: current progress and future directions of antipsychotic treatments[J]. Journal of Bio-X Research, 2019, 2(4): 145-152.

12.Zhou W, Shi Y, Li F, Wu X, Huai C, Shen L, Yi Z, He L, Liu C, Qin S*. Study of the association between Schizophrenia and microduplication at the 16p11.2 locus in the Han Chinese population[J]. Psychiatry Research, 2018, 265: 198-199.

13.Song X, Zhou K, Zhao Y, Huai C, Zhao Y, Yu H, Chen Y, Chen G, Chen H, Fan W, Mao Y*, Lu D*. Fine mapping analysis of a region of 20q13.33 identified five independent susceptibility loci for glioma in a Chinese Han population[J]. Carcinogenesis, 2012, 33(5): 1065-1071.

14.周翔达, 宋晓, 怀聪, 孙海燕, 陈红岩, 卢大儒*. 耐热DNA连接酶介导的TLCR技术在简化DNA重组实验中的应用. 遗传, 2016, 38(2):163-169.（技术开发）

15.皮妍, 李晓莹, 怀聪, 王诗铭, 乔守怡*, 卢大儒*. 以人类血型为遗传学案例教学的思考与实践. 遗传, 2013. 35(8): 1040-1044. （教法论文）

16. Qin S., Ma J., Huai C., Zhou W. Pharmacogenomics of Psychiatric Drugs[B]. In: Cai W., Liu Z., Miao L., Xiang X. (eds) Pharmacogenomics in Precision Medicine. Springer, Singapore. (2020) https://doi.org/10.1007/978-981-15-3895-7_6 （Book Chapter）

# 并列第一作者， * 通讯作者