主持和参与上海市自然科学基金，国家重大科学研究计划和重大专项等多个项目。在Nature, Small, Advanced materials, ACS AMI，Nanoscale和Plos等杂志发表多篇论文，获得多项国家发明专利。

1、DNA纳米技术，纳米技术和生物学的交叉研究

2、基因组和基因编辑的相关研究

1、Ma, Q., Cheng, L*., Gong, F., Dong, Z., Liang, C., Wang, M., Feng, L., Li, Y., Liu, Z.,Li, C*., He, L.Platinum Nanoworms for Imaging-guided Combined Cancer Therapy in the Second Near-infrared Window.Journal of Materials Chemistry B, 2018.

2、 Yang, J., Jiang, Q., He, L., Zhan, P., Liu, Q., Liu, S., Fu, M., Liu, J, Li, C*., Ding, B*.Self-Assembled Double Bundle DNA Tetrahedron for Efficient Antisense Delivery.ACS Applied Materials & Interface, 2018.

3、 Qu, Y., Yang, J., Zhan, P., Liu, S., Zhang, K., Jiang, Q, Li C*., Ding B*.Self-Assembled DNA Dendrimer Nanoparticle for Efficient Delivery of Immunostimulatory CpG Motifs.ACS Applied Materials & Interface, 2017.

4、Feng, X., Zhou, C., Niu, D., Zhao, J., Yang, J., He, L*., Li, C*.Yield Improving Strategy for SNP Detection on DNA Origami Chip by Employing Au Nanoparticles.Current Organic Chemistry, 2014.

5、Zhou, C., Luo, H., Feng, X., Li, X., Zhu, J., He, L*., Li, C*.FOLDNA, a Web Server for Self-Assembled DNA Nanostructure Autoscaffolds and Autostaples.Journal of Nanotechnology, 2012.

6、 Zhang, Z., Zeng, D., Ma, H., Feng, G., Hu, J., He, L.*, Li, C*., Fan, C*.A DNA-Origami Chip Platform for Label-Free SNP Genotyping Using Toehold-Mediated Strand Displacement.Small, 2010.

7、 Zhu, J., Feng, X., Lou, J., Li, W., Li, S., & Zhu, H., Yang, L., Zhang, A., He, L*., Li, C*.Accurate Quantification of Microrna via Single Strand Displacement Reaction on DNA Origami Motif.Plos One, 2013.

8、Zhang, Z., Fu, Y., Li, B., Feng, G., Li, C*., Fan, C., He, L*. Self-Assembly-Based Structural DNA Nanotechnology.Current Organic Chemistry, 2011.

#并列第一作者 *通讯作者