遗传生物学家，中国科学院院士，发展中国家科学院院士，。上海交通大学教授，Bio-X研究院院长，上海交通大学学术委员会副主任；复旦大学教授、生物医学研究院院长；中国科学院研究员，营养所课题负责人等。发表SCI论文300多篇。目前被聘为Biological Experiment and Medicine等副主编，及Psychiatric Genetics, Human Genetics等十多种科学杂志的编委。

疾病与健康（主要集中在单基因病和精神疾病为主的多基因病)，营养与健康，转化医学，药物基因组学，DNA计算与技术等。

1.Shi Y#*, Li Z#, Xu Q#, ……, He L*. Common Variants on 8p12 and 1q24.2 Confer Risk of Schizophrenia. Nat Genet. 2011;43(12):1224-7.

2.Chen P#, Pan D#, Fan C, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y *. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nat Nanotechnol. 2011;6(10):639-44.

3.Li R#, Fan W#, Tian G#, Zhu H#, He L#, Cai J#, ……, Wang J*. The sequence and de novo assembly of the giant pandagenome. Nature. 2010; 463(7279):311-7.

4.Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signaling capacity and range. Nature. 2009; 458(7242):1196-200.

5.O'Donovan MC, ……, He L, ……, Owen MJ. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40(9):1053-1055.

6.St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P*,  He L*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005; 294(5):557-62.

7.Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001; 28(4):386-8.

#并列第一作者 *通讯作者

目前主持国家自然科学基金青年科学基金项目，担任第五届中国药理学会药物基因组学专业委员会委员。

精神疾病的遗传学和药物基因组学研究，以及出生缺陷的致病机制研究。

1.Xiaohui Gong#, Xi Wu#, Xiaojing Ma, Dandan Wu, Ting Zhang, Li He, Shengying Qin*, Xiaotian Li*, Microdeletion and Microduplication Analysis of ChineseConotruncal Defects Patients with Targeted Array Comparative Genomic Hybridization, PLoS One, 2013 Oct 2, 8(10):e76314.

2.Xi Wu, Qingqing Xu, Liang Guo, Chuanting Yu, Yuyu Xiong, Zhiyun Wei, Ran Huo, Shengtian Li, Lu Shen, Jiamin Niu, Lu Liu, Yi Lin, Lin He*, Shengying Qin*, Quantitative Assessment of the Association between rs2046210 at 6q25.1 and Breast Cancer Risk, PLoS One, 2013 Jun 13, 8(6):e65206.

3.Xi Wu#, KeFu Tang#, Yang Li, YuYu Xiong, Lu Shen, ZhiYun Wei, KeJun Zhou, Jia Min Niu, Xia Han, Lun Yang, GuoYin Feng, Lin He*, ShengYing Qin*, Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis, Parkinsonism Relat Disord, 2012 Jul, 18(6):722-30.

4.Qingqing Xu, Xi Wu, Mo Li, Hailiang Huang, Camelia Minica, Zhenghui Yi, Guoqiang Wang, Lu Shen, Qinghe Xing, Yongyong Shi, Lin He, Shengying Qin*, Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population, Pharmacogenomics J, 2016 Aug;16(4):357-65.

5.Sun Q, Yuan F, Ren D, Ma G, Yang F, Wu X, He L, He G. GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity. Neuropsychiatr Dis Treat. 2019 Mar 7;15:657-661.

6.Shen L, Ma G, Shi Y, Ruan Y, Yang X, Wu X, Xiong Y, Wan C, Yang C, Cai L, Xiong L, Gong X, He L, Qin S. p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation. BMC Genet. 2019 Jan 16;20(1):10.

7.Ma G, Huang X, Bi Y, Ren D, Xu F, Sun Q, Zhang R, Hu J, Niu W, Guo Z, Yuan R, Yuan F, Wu X, Cao Y, Yang F, Wang L, Li W, Yu T, He L, Liu J, He G, Li X. Association study between ABCB1, ABCB6 and ABCG1 polymorphisms and major depressive disorder in the Chinese Han population. Psychiatry Res. 2018 Dec;270:1170-1171.

8.Zhou W, Shi Y, Li F, Wu X, Huai C, Shen L, Yi Z, He L, Liu C, Qin S. Study of the association between Schizophrenia and microduplication at the 16p11.2 locus in the Han Chinese population. Psychiatry Res. 2018 Jul;265:198-199.

#并列第一作者 *通讯作者

上海交通大学BIO-X研究院伦理委员会秘书。南京师范大学学士，复旦大学博士。复旦上海医学院讲师，哈佛公共卫生学院Research Fellow。主持了国家自然科学基金，教育部“留学回国人员”科研启动基金，校青年科学基金。

现主要研究精神性疾病与炎症的关系。利用群体遗传学方法研究发现致病的遗传等因素，并用分子生物学，蛋白质组学等多种方法验证有关群体遗传的研究结果。

1.Lei Cai*, Shao-Li Deng, Li Liang, Hui Pan, Jia Zhou, Mei-Yan Wang, Jun Yue, Chun-Ling Wan, Guang He, Lin He. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population (2013). Human Genetics. 132:265-273.

2.Lei Cai*, Wei Huang, Kuo-Chen Chou. Prostate cancer with variants in CYP17 and UGT2B17 genes: A meta-analysis (2012). Protein & Peptide Letters.19: 62-69.

3.Lei Cai*, Ying Wang, Jing-Fang Wang, Kuo-Chen Chou. Identification of proteins interacting with human SP110 during the process of viral infections (2011). Medicinal Chemistry. 7:121-126.

4.Lei Cai*, Hui Pan, Krzysztof Trzciński, Claudette M. Thompson, Qiang Wu and Igor Kramnik (2010). MYBBP1A: a new Ipr1's binding protein in mice. Molecular Biology Reports. 37: 3863-3868.

5.Lei Cai, Dongqing Zhang, Yeqing Shi, MK Oaks, Lishan Chen, Jianzhong Jin, Jie Qian, Fang Du, Ningli Li, Xinghai Han and Daming Ren (2005). Association of the CTLA-4 Gene with Rheumatoid Arthritis in Chinese Han Population. European Journal of Human Genetics. 13: 823-828.

6.Lei Cai, Guomei Tang, Lishan Chen, Bosheng Zhang, Sanduo Jiang and Daming Ren (2005). Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer’s disease patients. NeuroReport. 16: 1023-1026.

#并列第一作者 *通讯作者