遗传生物学家，中国科学院院士，发展中国家科学院院士，“长江学者”特聘教授，国家杰青。上海交通大学教授，Bio-X研究院院长，上海交通大学学术委员会副主任；复旦大学教授、生物医学研究院院长；中国科学院研究员，营养所课题负责人。两任国家973计划首席科学家，国家863计划专家，国家自然科学基金委员会评委，国务院学位评定委员会成员。发表SCI论文300多篇。目前被聘为Biological Experiment and Medicine等副主编，及Psychiatric Genetics, Human Genetics等十多种科学杂志的编委。

疾病与健康（主要集中在单基因病和精神疾病为主的多基因病)，营养与健康，转化医学，药物基因组学，DNA计算与技术等。

1.Shi Y#*, Li Z#, Xu Q#, ……, He L*. Common Variants on 8p12 and 1q24.2 Confer Risk of Schizophrenia. Nat Genet. 2011;43(12):1224-7.

2.Chen P#, Pan D#, Fan C, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y *. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nat Nanotechnol. 2011;6(10):639-44.

3.Li R#, Fan W#, Tian G#, Zhu H#, He L#, Cai J#, ……, Wang J*. The sequence and de novo assembly of the giant pandagenome. Nature. 2010; 463(7279):311-7.

4.Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D. A mutation in Ihh that causes digit abnormalities alters its signaling capacity and range. Nature. 2009; 458(7242):1196-200.

5.O'Donovan MC, ……, He L, ……, Owen MJ. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008;40(9):1053-1055.

6.St Clair D, Xu M, Wang P, Yu Y, Fang Y, Zhang F, Zheng X, Gu N, Feng G, Sham P*,  He L*. Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA. 2005; 294(5):557-62.

7.Gao B, Guo J, She C, Shu A, Yang M, Tan Z, Yang X, Guo S, Feng G, He L*. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1. Nat Genet. 2001; 28(4):386-8.

#并列第一作者 *通讯作者

目前主持国家自然科学基金青年科学基金项目，担任第五届中国药理学会药物基因组学专业委员会委员。

精神疾病的遗传学和药物基因组学研究，以及出生缺陷的致病机制研究。

1.Xiaohui Gong#, Xi Wu#, Xiaojing Ma, Dandan Wu, Ting Zhang, Li He, Shengying Qin*, Xiaotian Li*, Microdeletion and Microduplication Analysis of ChineseConotruncal Defects Patients with Targeted Array Comparative Genomic Hybridization, PLoS One, 2013 Oct 2, 8(10):e76314.

2.Xi Wu, Qingqing Xu, Liang Guo, Chuanting Yu, Yuyu Xiong, Zhiyun Wei, Ran Huo, Shengtian Li, Lu Shen, Jiamin Niu, Lu Liu, Yi Lin, Lin He*, Shengying Qin*, Quantitative Assessment of the Association between rs2046210 at 6q25.1 and Breast Cancer Risk, PLoS One, 2013 Jun 13, 8(6):e65206.

3.Xi Wu#, KeFu Tang#, Yang Li, YuYu Xiong, Lu Shen, ZhiYun Wei, KeJun Zhou, Jia Min Niu, Xia Han, Lun Yang, GuoYin Feng, Lin He*, ShengYing Qin*, Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis, Parkinsonism Relat Disord, 2012 Jul, 18(6):722-30.

4.Qingqing Xu, Xi Wu, Mo Li, Hailiang Huang, Camelia Minica, Zhenghui Yi, Guoqiang Wang, Lu Shen, Qinghe Xing, Yongyong Shi, Lin He, Shengying Qin*, Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population, Pharmacogenomics J, 2016 Aug;16(4):357-65.

5.Sun Q, Yuan F, Ren D, Ma G, Yang F, Wu X, He L, He G. GSK-3β and BDNF genes may not be associated with venlafaxine treatment response in Chinese of Han ethnicity. Neuropsychiatr Dis Treat. 2019 Mar 7;15:657-661.

6.Shen L, Ma G, Shi Y, Ruan Y, Yang X, Wu X, Xiong Y, Wan C, Yang C, Cai L, Xiong L, Gong X, He L, Qin S. p.E95K mutation in Indian hedgehog causing brachydactyly type A1 impairs IHH/Gli1 downstream transcriptional regulation. BMC Genet. 2019 Jan 16;20(1):10.

7.Ma G, Huang X, Bi Y, Ren D, Xu F, Sun Q, Zhang R, Hu J, Niu W, Guo Z, Yuan R, Yuan F, Wu X, Cao Y, Yang F, Wang L, Li W, Yu T, He L, Liu J, He G, Li X. Association study between ABCB1, ABCB6 and ABCG1 polymorphisms and major depressive disorder in the Chinese Han population. Psychiatry Res. 2018 Dec;270:1170-1171.

8.Zhou W, Shi Y, Li F, Wu X, Huai C, Shen L, Yi Z, He L, Liu C, Qin S. Study of the association between Schizophrenia and microduplication at the 16p11.2 locus in the Han Chinese population. Psychiatry Res. 2018 Jul;265:198-199.

#并列第一作者 *通讯作者

上海交通大学BIO-X研究院伦理委员会秘书。南京师范大学学士，复旦大学博士。复旦上海医学院讲师，哈佛公共卫生学院Research Fellow。主持了国家自然科学基金，教育部“留学回国人员”科研启动基金，校青年科学基金。

现主要研究精神性疾病与炎症的关系。利用群体遗传学方法研究发现致病的遗传等因素，并用分子生物学，蛋白质组学等多种方法验证有关群体遗传的研究结果。

1.Lei Cai*, Shao-Li Deng, Li Liang, Hui Pan, Jia Zhou, Mei-Yan Wang, Jun Yue, Chun-Ling Wan, Guang He, Lin He. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population (2013). Human Genetics. 132:265-273.

2.Lei Cai*, Wei Huang, Kuo-Chen Chou. Prostate cancer with variants in CYP17 and UGT2B17 genes: A meta-analysis (2012). Protein & Peptide Letters.19: 62-69.

3.Lei Cai*, Ying Wang, Jing-Fang Wang, Kuo-Chen Chou. Identification of proteins interacting with human SP110 during the process of viral infections (2011). Medicinal Chemistry. 7:121-126.

4.Lei Cai*, Hui Pan, Krzysztof Trzciński, Claudette M. Thompson, Qiang Wu and Igor Kramnik (2010). MYBBP1A: a new Ipr1's binding protein in mice. Molecular Biology Reports. 37: 3863-3868.

5.Lei Cai, Dongqing Zhang, Yeqing Shi, MK Oaks, Lishan Chen, Jianzhong Jin, Jie Qian, Fang Du, Ningli Li, Xinghai Han and Daming Ren (2005). Association of the CTLA-4 Gene with Rheumatoid Arthritis in Chinese Han Population. European Journal of Human Genetics. 13: 823-828.

6.Lei Cai, Guomei Tang, Lishan Chen, Bosheng Zhang, Sanduo Jiang and Daming Ren (2005). Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer’s disease patients. NeuroReport. 16: 1023-1026.

#并列第一作者 *通讯作者

余涛，博士，上海交通大学Bio-X研究院助理教授，上海市精神卫生中心双聘PI，贺林院士团队成员。毕业于四川大学华西心理卫生中心，在上海交通大学和英国伦敦国王大学（KCL）完成博士后研究，曾在美国国立精神卫生研究所（NIMH）、美国德克萨斯大学圣安东尼奥医学院进行访问学者研究。主持或参与了多个国家级、省部级课题，包括国家重点研发计划“精准医学研究”重点专项、国家重大慢性非传染性疾病防控研究、国家自然科学基金、上海市妇幼健康协同创新筹建项目以及上海交通大学文理交叉重点专项等。在国内外知名期刊上发表SCI论文50余篇，参编专著3部。首批认知神经心理学专家组成员。

通过融合影像遗传学、认知神经科学、人工智能及脑机接口等的跨学科研究，聚焦儿童学习困难和认知功能障碍的神经机制，开发新型干预治疗方法。致力于“中国数字”的推广，发展具有中国特色的学习困难与认知障碍干预策略，推动脑科学与人工智能在临床康复和教育领域中的应用与发展。

2、Robert, Gabriel H., Qiang Luo, Tao Yu, Congying Chu, Alex Ing, Tianye Jia, Dimitri Papadopoulos Orfanos et al. "Association of gray matter and personality development with increased drunkenness frequency during adolescence." JAMA psychiatry  (2020).

3、Ji, Lei, Changfeng Chen, Binyin Hou, Decheng Ren, Fan Yuan, Liangjie Liu, Yan Bi, Shi Yi, Tao Yu*, He Guang*. "A study of negative life events driven depressive symptoms and academic engagement in Chinese college students." Scientific Reports (2021).

*共同通讯作者