李保界博士，上海市千人计划特聘教授。上海交通大学Bio-X研究院副院长及干细胞与发育研究中心主任。回国之前，在新加坡Institute of Molecular and Cell Biology担任PI（assistant, associate professor）。主持科技部重大科学研究计划、国家自然科学重点和面上项目等基金。共发表60余篇SCI论文。现为中国老年学学会衰老与抗衰老科学委员会副主任委员以及国际杂志BMC Developmental Biology 副主编。

间充质干细胞体内自我更新、分化以及衰老的调控机制；骨骼发育、骨代谢以及骨质疏松症的发病机理；DNA损伤应激发应、衰老以及肿瘤发生。

1. Keng Po Lai, Wai Fook Leong, Jenny Fung Ling Chau, Deyong Jia, Li Zeng, Huijuan Liu, Aijun Hao, Lin He, Hongbing Zhang, David Meek, Chakradhar Velagapudi, Samy L. Habib, and Baojie Li* (2010). S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J., 29(17):2994-3006

2. Gang Ma, Lili Li, Yuanyu Hu, Bijin Au, Lin He and Baojie Li* (2012).  Atypical Atm-p53 interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol, 4(2): 118-120.

3. Jenny Chau, Yuanyu Hu,  Jianhe Wang, Zhi Liu, Bi Jin Au, Yuji Mishina, Ye-Guang Chen, Christine Biondi, Elizabeth Robertson, Yue-Zheng Du, Dong Xie, Xueying Wang, Qiang Yu, and Baojie Li* (2012).  A crucial role for BMP-Smad1 signaling in the DNA damage response. Nature Communications, 2012 May 15; 3:836.

4. Kua HY, Liu H, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, Boast S, Yeh J, Xia L, Chen GQ, He L, Goff SP, and Baojie Li *(2012) c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression. Nature Cell Biology. 14(7):727-37

5. Huijuan Liu, Deyong Jia, Jenny Chau, Lin He and Baojie Li* (2013). p53 regulates neural stem cell self-renewal and differentiation via BMP-Smad1-Id1 pathway.  Stem Cell Dev. 15;22(6):913-27.

6. Hao Jia, Jenny Fang Ling Chau, Qian Cong, and Baojie Li* (2014).  A critical role for p57Kip2 in the DNA damage response.  Oncogene.  2014 Sep 8. doi: 10.1038/onc.2014.287. [Epub ahead of print].

7. Bing Qi1 , Qian Cong 2 , Ping Li2, Gang Ma2, Xizhi Guo2, Min Xie3, Michael D. Schneider4, Huijuan Liu2, #, andBaojie Li* (2014) Ablation of Tak1 in monocyte leads to defects in skeletal growth and bone remodeling in mice.  Scientific Reports, Nov 24; 4:7158.

8. Xinsen Ruan1,*, Qiao Zuo2,*, Jenny Chua3, Hao Jia1, Jinlin Lin1, Xuechun Xia1, Huijuan Liu1, Samy L. Habib4, Chuangang Fu2, 5, and Baojie Li*.  p53 deficiency-induced Smad1 up-regulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.  J Mol Cell Biol. 2015 Mar 10. pii: mjv015. [Epub ahead of print]

#并列第一作者 *通讯作者

刘慧娟博士，目前主持国家自然基金青年项目，作为科研骨干参与国家973项目、国家自然基金重点项目等。

间充质干细胞体内自我更新、分化以及衰老的调控机制；DNA损伤应激发应、衰老以及肿瘤发生。

1.Kua HY#, Liu Huijuan#, Leong WF, Li L, Jia D, Ma G, Hu Y, Wang X, Chau JF, Chen YG, Mishina Y, He L, Goff SP, Li B. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16(INK4a) expression. Nat Cell Biol. 2012;24;14(7):727-37.

2.Liu Huijuan, Jia D, Li A, Chau J, He D, Ruan X, Liu F, Li J, He L, Li B. p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1. Stem Cells Dev. 2013;22(6):913-27.

3.Liu Huijuan, Li B. p53 control of bone remodeling. J Cell Biochem. 2010;111(3):529-34.

4.Liu Huijuan, Jia D, Fu J, Zhao S, He G, Ling EA, Gao J, Hao A. Effects of granulocyte colony-stimulating factor on the proliferation and cell-fate specification of neural stem cells.  Neuroscience. 2009;164(4):1521-30.

5.Lai KP, Leong WF, Chau JF, Jia D, Zeng L, Liu Huijuan, He L, Hao A, Zhang H, Meek D, Velagapudi C, Habib SL, Li B. S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J. 2010;29(17):2994-3006.

6.Ma G, Li L, Hu Y, Chau JF, Au BJ, Jia D, Liu Huijuan, Yeh J, He L, Hao A, Li B. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol. 2012;4(2):118-20.

7.Jia DY#, Liu huijuan#, Wang FW, Liu SM, Ling EA, Liu K, Hao AJ. Folic acid supplementation affects apoptosis and differentiation of embryonic neural stem cells exposed to high glucose. Neurosci Lett. 2008;440(1):27-31.

#并列第一作者 *通讯作者

上海交通大学助理研究员，主要从事间质细胞异质性和功能的研究，相关工作以第一/共一作者身份发表SCI论文5篇，申请并主持国自然青年科学基金项目（C类）和上海市自然科学基金项目各一项。

成年小鼠骨、皮肤、脂肪组织中间质细胞相关亚群的组成及功能。

1. Hongshang Chu#; Shaoyang Zhang#; Zhenlin Zhang; Hua Yue; Huijuan Liu; Baojie Li; Feng Yin;Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment, npj Regenerative Medicine, 2024, 9(1)

2. Huijuan Liu#; Ping Li#; Shaoyang Zhang#; Jinnan Xiang; Ruichen Yang; Jiajia Liu; Md Shafiquzzaman; Soma Biswas; Zhanying Wei; Zhanying Wei; Xin Zhou; Feng Yin; Yangli Xie; Stephen P. Goff; Lin Chen; Baojie Li; Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice, Nature Genetics, 2022, 54(12): 1946-1958

3. Shaoyang Zhang; Jing Yi Wang; Baojie Li; Feng Yin; Huijuan Liu; Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells, Stem Cell Research amp; Therapy, 2021, 12(1)

4.   Chao Zhou#; Shaoyang Zhang#; Jing Ai; Ping Li; Yanjie Zhao; Baojie Li; Lu Han; Yingying Duan; Shunai Che; Enantioselective Interaction between Cells and Chiral Hydroxyapatite Films, Chem. Mater, 2021, 34(1): 53-62

5.   Jinnan Xiang#; Shaoyang Zhang#; Ruiyao Xu; Hongshang Chu; Soma Biswas; Shuxiang Yu; Dengshun Miao; Weidong Li; Shentian Li; Andrew J. Brown; Hongyuan Yang; Yuhong Xu; Baojie Li; Huijuan Liu ; Elevated HB-EGF expression in neural stem cells causes middle age obesity by suppressing Hypocretin/Orexin expression, The FASEB Journal, 2021, 35(4)

6.     Shaoyang Zhang#; Limei Zhong#; Bing Chen; Ting Pan; Xue Zhang; Liting Liang; Qianwen Li; Ziying Zhang; Hui Chen; Jie Zhou; Haihua Luo; Hui Zhang; Chuan Bai ; Identification of an HIV-1 replication inhibitor which rescues host restriction factor APOBEC3G in Vif–APOBEC3G complex, Antiviral Research, 2015, 122(2015): 20-27