李丹，博士。2002年本科毕业于吉林大学，2008年博士毕业于北京大学，2008-2013年在美国加州大学洛杉矶分校（UCLA）/霍华德休斯医学院从事博士后研究。2017年加入上海交通大学，现任生命科学与技术学院副院长、Bio-X研究院副院长，博士生导师，课题组长，万人计划青年拔尖。

长期从事神经退行性疾病相关蛋白的相变和聚集机制研究，在蛋白相分离、淀粉样聚集及靶向蛋白聚集的诊断与干预领域取得了一系列重要突破。

蛋白相分离相变聚集、神经退行性疾病，靶向诊断与干预

方向1: 综合运用多种生物物理、生物化学和细胞生物学手段，研究生理和病理条件下的蛋白质相分离和无膜细胞器的组装与调控。

方向2: 研究神经退行性疾病，如阿尔兹海默症(AD)、帕金森症(PD)、渐冻人症(ALS)等，蛋白异常相变聚集的发生和致病机理。发展运用冷冻电镜电子衍射、螺旋纤维三维重构技术，解析蛋白淀粉样聚集纤维原子结构，阐释聚集体致病的分子机理, 开发相关疾病的治疗药物和临床诊断标记物。

1.     Yuxuan Yao#, Shun Yao#, Yamei Xu#, Qinyue Zhao, Xingyu Xiong, Kaien Liu, Yu Liu, Zhizhi Wang, Wenqing Xu, Cong Liu*, Jingmin Zhou*, Dan Li*. Cryo-EM structures of light chain fibrils from abdominal fat biopsies of multiple myeloma patients. Nat Commun. 2026 Feb 24. doi: 10.1038/s41467-026-69784-4.

2.     Yuxuan Yao#, Qinyue Zhao#, Shun Yao#, Yamei Xu, Kaien Liu, Tianyi Cao, Bo Sun, Jingmin Zhou*, Cong Liu*, Dan Li*. Biopsy-resolved cryo-EM structures of amyloid fibrils provide molecular insights into AL amyloidosis. Proc Natl Acad Sci U S A. 2026 Mar 3;123(9):e2529249123. doi: 10.1073/pnas.2529249123.

3.     Shuyi Zeng, Xingyu Xiong, Houfang Long, Qianhui Xu, Yifan Yu, Bo Sun, Cong Liu, Zhizhi Wang, Wenqing Xu, Shengnan Zhang, Dan Li*. Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities. Nat Commun. 2025 Aug 9;16(1):7368. doi: 10.1038/s41467-025-62755-1.

4.     Jiaqi Zhang#, Jiaojiao Hu#, Ruogu Liu#, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng*, Dan Li*, Bo Wang*. YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates. Nat Cell Biol. 2025 Jul;27(7):1148-1160. doi: 10.1038/s41556-025-01685-y. 

5.     Qinyue Zhao#, Youqi Tao#, Yuxuan Yao, Kaien Liu, Shiran Lv, Bingyao Cui, Weidi Xiao, Tianyi Cao, Weidong Li6, Feng Gao, Yong Shen, Chu Wang, Chao Ma, Wenying Qiu, Cong Liu*, Dan Li*. Unraveling Alzheimer's complexity with a distinct Aβ42 fibril type and specific AV-45 binding.  Nat Chem Biol. 2025 Jun 10. doi: 10.1038/s41589-025-01921-4.  

6.     Dan Li*, Kaien Liu, Danni Li, Axel Brunger, Cong Li, Jacqueline Burré, Jiajie Diao*. α-Synuclein condensation in synaptic vesicle function and synucleinopathies. Trends Cell Biol. 2025 Apr 29:S0962-8924(25)00087-X. doi: 10.1016/j.tcb.2025.03.007. 

7.     Chuchu Wang, Kai Zhang, Bin Cai, Jillian E Haller, Kathryn E Carnazza, Jiaojiao Hu, Chunyu Zhao, Zhiqi Tian, Xiao Hu, Daniel Hall, Jiali Qiang, Shouqiao Hou, Zhenying Liu, Jinge Gu, Yaoyang Zhang, Kim B Seroogy, Jacqueline Burré, Yanshan Fang, Cong Liu, Axel T Brunger*, Dan Li*, Jiajie Diao*. VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates. Nat Cell Biol. 2024 Aug;26(8):1287-1295. doi: 10.1038/s41556-024-01456-1.

8.     Hong Zhang, Huazhang Guo, Danni Li, Yiling Zhang, Shengnan Zhang, Wenyan Kang, Cong Liu, Weidong Le, Liang Wang*, Dan Li*, Bin Dai*. Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus. Nat Commun. 2024 Apr 6;15(1):2980. doi: 10.1038/s41467-024-47167-x.

9.     Youqi Tao#, Wencheng Xia#, Qinyue Zhao#, Huaijiang Xiang, Chao Han, Shenqing Zhang, Wei Gu, Wenjun Tang, Ying Li, Li Tan, Dan Li*, Cong Liu* Structural mechanism for specific binding of chemical compounds to amyloid fibrils, Nat Chem Biol., 2023 Oct;19(10):1235-1245. doi: 10.1038/s41589-023-01370-x.

10.   Jie Xiang#, Youqi Tao#, Yiyuan Xia#, Shilin Luo, Qinyue Zhao, Bowei Li, Xiaoqian Zhang, Yunpeng Sun, Wencheng Xia, Mingming Zhang, Seong Su Kang, Eun-Hee Ahn, Xia Liu, Fang Xie, Yihui Guan, Jenny J Yang, Lihong Bu, Shengxi Wu, Xiaochuan Wang, Xuebing Cao, Cong Liu, Zhentao Zhang*, Dan Li*, Keqiang Ye*, Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies, Cell, 2023 Aug 3;186(16):3350-3367.e19.  doi: 10.1016/j.cell.2023.06.004.

11.   Youqi Tao#, Yunpeng Sun#, Shiran Lv, Wencheng Xia, Kun Zhao, Qianhui Xu, Qinyue Zhao, Lin He, Weidong Le, Yong Wang, Cong Liu*, Dan Li*. Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology. Nat Commun. 2022 Jul 22;13(1):4226.

12.   Dan Li*, Cong Liu*. Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nat Rev Neurosci. 2022 May 30. doi: 10.1038/s41583-022-00603-7. (Invited review)

13.   Yun Fan #, Qinyue Zhao #, Wencheng Xia #, Youqi Tao, Wenbo Yu, Mingjia Chen, Yiqi Liu, Jue Zhao, Yan Shen, Yunpeng Sun, Chenfang Si, Shenqing Zhang, Yaoyang Zhang, Wensheng Li, Cong Liu, Jian Wang*, Dan Li*. Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Res. 2022 Jun;32(6):585-588. doi: 10.1038/s41422-022-00665-3.

14.   Dan Li*, Cong Liu*. Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks, Trend Cell Biol, 2022 Jan;32(1):1-3 (13.527). (Invited review)

15.   Dan Li* and Cong Liu*, Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Nat Chem Biol., 2021 Mar;17(3):237-245doi: 10.1038/s41589-020-00708-z. (Invited review)

16.   Yunpeng Sun#, Shouqiao Hou#, Kun Zhao#, Houfang Long, Zhenying Liu, Jing Gao, Yaoyang Zhang, Xiao-Dong Su, Dan Li*, Cong Liu*. Cryo-EM structure of full-length alpha-synuclein amyloid fibril with Parkinson's disease familial A53T mutation. Cell Res. 2020 Apr;30(4):360-362. doi: 10.1038/s41422-020-0299-4.

17.   Jinge Gu#, Zhenying Liu#, Shengnan Zhang, Yichen Li, Wencheng Xia, Chen Wang, Huaijiang Xiang, Zhijun Liu, Li Tan, Yanshan Fang, Cong Liu*, Dan Li*. Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31123-31133. doi: 10.1073/pnas.2002437117.

18.   Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Guoqin Feng, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Renxiao Wang, Cong Liu*, Dan Li*. The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure. Nat Commun. 2020 Dec 11;11(1):6349. doi: 10.1038/s41467-020-20227-8.

19.   Zhenying Liu#, Shengnan Zhang#, Jinge Gu#, Yilun Tong, Yichen Li, Xinrui Gui, Houfang Long, Chuchu Wang, Chunyu Zhao, Jinxia Lu, Lin He, Ying Li, Zhijun Liu, Dan Li*, Cong Liu*. Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. Nat Struct Mol Biol. 2020 Apr;27(4):363-372. doi: 10.1038/s41594-020-0399-3.Xinrui Gui, Feng Luo, Yichen Li, Heng Zhou, Zhenheng Qin, Zhenying Liu, Jinge Gu, Muyun Xie,, Kun Zhao, Bin Dai, Woo Shik Shin, Jianhua He, Lin He, Lin Jiang, Minglei Zhao, Bo Sun, Xueming Li, Cong Liu*, Dan Li*. Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly. Nat Commun, 2019 May 1;10(1):2006. doi: 10.1038/s41467-019-09902-7.

20.  Yaowang Li#, Chunyu Zhao#, Feng Luo#, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li*, Cong Liu*, Xueming Li*. Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy. Cell Res. 2018 Sep;28(9):897-903. doi: 10.1038/s41422-018-0075-x.

21.  Feng Luo#, Xinrui Gui#, Heng Zhou#, Jinge Gu, Yichen Li, Xiangyu Liu, Minglei Zhao, Dan Li*, Xueming Li*, Cong Liu*. Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation. Nat Struct Mol Biol. 2018 Apr;25(4):341-346. doi: 10.1038/s41594-018-0050-8.

神经退行性疾病的诊断、治疗药物开发

(1) Jiang Bian*; Yi-qi Liu*; et al; Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands, European Journal of Medicinal Chemistry, 2021, 226(113887)

(2) Jiang Bian; Lihui Zhang; et al; Histone Deacetylase Inhibitors: Potent Anti-Leukemic Agents, Current Medicinal Chemistry, 2015.春季, 22(17): 2065-2074

(3) Yanfei Chen*; Jiang Bian*; et al; Design, Synthesis and Identification of N, N-Dibenzylcinnamamide(DBC) Derivatives as Novel Ligands for α-synuclein Fibrils by SPR Evaluation System, Bioorganic & Medicinal Chemistry, 2020, 28(7)(115358)

(4) Shenqing Zhang*; Hui Dong*; Jiang Bian*; Dan Li; Cong Liu; Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases, Fundamental Research, 2023(3): 505-519

(5) Chenyang Qiu*; Ruonan Wei*; Jiang Bian*; Xin Lin; Tengfei Bai; Jie He; Xiaomin Guo; YongChu; Novel 4-triazole phenyl amide (4-TPA) molecules: Potent promoters of α-synuclein fibril disassembly, European Journal of Medicinal Chemistry, 2024, 273(5)