学习工作经历：

2023至今    中国科学院脑科学与智能技术卓越创新中心副主任（主持工作）；

2022至今    上海交通大学Bio-X研究院院长；

2022至今    Progress in Neuropsychopharmacology & Biological Psychiatry杂志副主编

2019 ~ 2024 上海交通大学生命科学技术学院副院长；

2018至今    “Research”杂志副主编；

2014至今    上海交通大学特聘教授（Distinguished Professor）；

2014 ~ 2024 “Hereditas”杂志主编；

2019 ~ 2022 上海交通大学Bio-X研究院执行院长；

2008 ~ 2013, 上海交通大学研究员;

2006 ~ 2008, 上海交通大学副教授;

学术兼职：Research杂志（AAAS）副主编、Progress in Neuropsychopharmacology & Biological Psychiatry杂志副主编、Hereditas杂志十年主编（2014-2024）、中国遗传学会理事、上海市遗传学会理事会理事、上海市神经科学学会理事。

获得荣誉：谈家桢生命科学奖创新奖等，上海市科技精英、上海市青年科技杰出贡献奖、首届教育部青年科学奖等，首批中组部青年拔尖人才，中青年科技创新领军人才，上海市十大杰出青年等，上海市优秀学术带头人，全国优秀博士论文，教育部新世纪优秀人才，上海市青年科技英才，上海市曙光学者，上海市科技启明星，霍英东青年教师奖，明治生命科学奖等。

科研业绩：承担国自然重点项目、863计划重大专项、973青年科学家项目、科技部重点研发项目等。发表SCI论文300余篇，总引用超2.4万次，H-Index 67（Google Scholar）；2019年至今持续入选爱思唯尔高被引学者；以通讯作者和（或）第一作者身份在 《Nature Nanotechnology》、 《Nature Genetics》、《Cell Research》杂志上发表了19篇论文；以第一完成人身份获得国家自然科学二等奖1项、上海市自然科学奖一等奖1项、教育部自然科学一等奖1项，并以第一发明人身份取得了23项发明专利（10项美国专利）和3项软件著作权授权。

脑疾病分子机理；基因组学、神经科学、生物信息学、合成生物学交叉学科领域

1.        Zhao H^#*, Xu Y^#, Xue B^#, Zhao S^#, Zhang M^#, Wu X, Wang T, Wen Y, Li S, Zhang Q, Yang Z, Sun H, Pan T, Lian Y, Gao X, Gao C, Wang Z, Wu C, Zhang C, Jian X, Peng L, Zhang X, Wang B, Wei L, He Y, Xia Y, Wu Z, Yang Q, Sun Y, Ding Y, Du S, Xia G, Jing Y, Xu H, Shi W, Liu J, He L, Chen Z, Cao Y^*, Li Z^*, Shi Y^*. New Insights into Genetic Susceptibility of Polycystic Ovary Syndrome. Nature Genetics. 2025 Nov; 57:2669-2681.

2.        Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, Song Z, Ji W, Wang M, Zhou J, Chen B, Liu Y, Wang J, Wang P, Yang P, Wang Q, Feng G, Liu B, Sun W, Li B, He G, Li W, Wan C, Xu Q, Li W, Wen Z, Liu K, Huang F, Ji J, Ripke S, Yue W, Sullivan P, Donovan M, Shi Y^*. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nature Genetics. 2017 Nov;49(11):1576-1583.

3.        Lam M^#, Chen CY^#, Li Z, Martin AR, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown BC, Liu R, Zhou W, Guan L, Kamatani Y, Kim SW, Kubo M, Kusumawardhani AAAA, Liu CM, Ma H, Periyasamy S, Takahashi A, Xu Z, Yu H, Zhu F; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Indonesia Schizophrenia Consortium; Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), Chen WJ, Faraone S, Glatt SJ, He L, Hyman SE, Hwu HG, McCarroll SA, Neale BM, Sklar P, Wildenauer DB, Yu X, Zhang D, Mowry BJ, Lee J, Holmans P, Xu S, Sullivan PF, Ripke S, O'Donovan MC, Daly MJ, Qin S, Sham P, Iwata N, Hong KS, Schwab SG, Yue W^*, Tsuang M^*, Liu J^*, Ma X^*, Kahn RS^*, Shi Y^*, Huang H^*. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics. 2019 Dec;51(12):1670-1678.

4.        Xu H, Liu F, Li Z, Li X, Liu Y, Li N, Zhang X, Gao Z, Zhang X, Liu Y, Zou J, Meng L, Liu S, Zhu H, Tang X, Wu H, Su K, Chen B, Yu D, Ye H, Chen H, Yi H, Guan J^*, Yin S^*, Shi Y^*. Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-Related Traits Identifies Novel Risk Loci in Han Chinese Individuals. American Journal of Respiratory and Critical Care Medicine. 2022 Jul 12. doi: 10.1164/rccm.202109-2044OC.

5.        Chang K, Jian X, Wu C, Gao C, Li Y, Chen J, Xue B, Ding Y, Peng L, Wang B, He L, Xu Y, Li C, Li X, Wang Z, Zhao X, Pan D, Yang Q, Zhou J, Zhu Z, Liu Z, Xia D, Feng G, Zhang Q, Wen Y, Shi Y^*, Li Z^*. The Contribution of Mosaic Chromosomal Alterations to Schizophrenia. Biological Psychiatry. 2025 Jan 15; 97(2):198-207. doi: 10.1016/j.biopsych.

6.        Yang Q, Xia D, Syed AAS, Wang Z, Shi Y^*. Highly accurate protein structure prediction and drug screen of monkeypox virus proteome. Journal of Infection. 2022 Aug 11: S0163-4453(22)00470-4.

7.        Yang Q, Jian X, Syed AAS, Fahira A, Zheng C, Zhu Z, Wang K, Zhang J, Wen Y, Li Z, Pan D, Lu T, Wang Z, Shi Y^*. Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants. Research (Wash D C). 2022 Feb 1;2022:9781758. doi: 10.34133/2022/9781758. eCollection 2022.

8.        Yang Q, Syed AAS, Fahira A, Shi Y^*. Structural Analysis of the SARS-CoV-2 Omicron Variant Proteins. Research (Wash D C). 2021 Dec 28;2021:9769586. doi: 10.34133/2021/9769586. eCollection 2021.

9.        Shi YY, He L^*. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Research. 2005, 15(2), 97-8.

10.    Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, He L^*, Shi Y^*. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Research. 2009 Apr;19(4):519-23.

11.    Chen P, Pan D, Fan C^*, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y^*. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nature Nanotechnology. 2011 Sep 4;6(10):639-44. doi: 10.1038/nnano.2011.141.

12.    Shi Y^*, Li Z, Xu Q, Wang T, Li T, Shen J, Zhang F, Chen J, Zhou G, Ji W, Li B, Xu Y, Liu D, Wang P, Yang P, Liu B, Sun W, Wan C, Qin S, He G, Steinberg S, Cichon S, Werge T, Sigurdsson E, Tosato S, Palotie A, Nöthen MM, Rietschel M, Ophoff RA, Collier DA, Rujescu D, Clair DS, Stefansson H, Stefansson K, Ji J, Wang Q, Li W, Zheng L, Zhang H, Feng G, He L^*. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genetics. 2011 Oct 30;43(12):1224-7. doi: 10.1038/ng.980.

13.    Shi Y^*, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D^*, Shen H^*. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nature Genetics. 2011 Oct 30;43(12):1215-8. doi: 10.1038/ng.978.

14.    Shi Y^*, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y, Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X^*, Ma D^*. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. Nature Genetics. 2013 Aug;45(8):918-22. doi: 10.1038/ng.2687. Epub 2013 Jun 30.

15.    Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L^*, Chen ZJ^*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics. 2012 Sep;44(9):1020-5.

16.    Chen J, Jian X, Deng S, Ma Z, Shou X, Shen Y, Zhang Q, Song Z, Li Z, Peng H, Peng C, Chen M, Luo C, Zhao D, Ye Z, Shen M, Zhang Y, Zhou J, Fahira A, Wang Y, Li S, Zhang Z, Ye H, Li Y, Shen J, Chen H, Tang F, Yao Z, Shi Z, Chen C, Xie L, Wang Y, Fu C, Mao Y, Zhou L, Gao D, Yan H, Zhao Y^*, Huang C^*, Shi Y^*. Identification of recurrent USP48 and BRAF mutations in Cushing's disease. Nature Communications. 2018 Aug 9;9(1):3171.

17.    Li Z, Chen J, Zhao Y, Wang Y, Xu J, Ji J, Shen J, Zhang W, Chen Z, Sun Q, Mao L, Cheng S, Yang B, Zhang D, Xu Y, Zhao Y, Liu D, Shen Y, Zhang W, Li C, Shen J, Shi Y^*. Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea. Nature Communications. 2017 Apr 27;8:14900. doi: 10.1038/ncomms14900.

18.    Li Z, Chen J, Xu Y, Yi Q, Ji W, Wang P, Shen J, Song Z, Wang M, Yang P, Wang Q, Feng G, Liu B, Sun W, Xu Q, Li B, He L, He G, Li W, Wen Z, Liu K, Huang F, Zhou J, Ji J, Li X, Shi Y^*. Genome-wide Analysis of the Role of Copy Number Variation in Schizophrenia Risk in Chinese. Biological Psychiatry. 2016 Aug 15;80(4):331-7. doi: 10.1016/j.biopsych.2015.11.012.

19.    Li C^*, Li Z, Liu S, Wang C, Han L, Cui L, Zhou J, Zou H, Liu Z, Chen J, Cheng X, Zhou Z, Ding C, Wang M, Chen T, Cui Y, He H, Zhang K, Yin C, Wang Y, Xing S, Li B, Ji J, Jia Z, Ma L, Niu J, Xin Y, Liu T, Chu N, Yu Q, Ren W, Wang X, Zhang A, Sun Y, Wang H, Lu J, Li Y, Qing Y, Chen G, Wang Y, Zhou L, Niu H, Liang J, Dong Q, Li X, Mi QS, Shi Y^*. Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese. Nature Communications. 2015 May 13;6:7041. doi: 10.1038/ncomms8041.

20.    Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y^*. Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population. Molecular Psychiatry. 2011 May;16(5):473-5.

21.    Li J, Zhou G, Ji W, Feng G, Zhao Q, Liu J, Li T, Li Y, Chen P, Zeng Z, Wang T, Hu Z, Zheng L, Wang Y, Shen Y, He L, Shi Y^*. Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia. Archives of General Psychiatry. 2011 Mar;68(3):232-40.

22.    Shi Y, Zhao X, Yu L, Tao R, Tang J, La Y, Duan Y, Gao B, Gu N, Xu Y, Feng G, Zhu S, Liu H, Salter H, He L. Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. Genome Research. 2004, 14(7), 1345-9.

23.    Li T, Li Z, Chen P, Zhao Q, Wang T, Huang K, Li J, Li Y, Liu J, Zeng Z, Feng G, He L, Shi Y^*. Common Variants in Major Histocompatibility Complex Region and TCF4 Gene Are Significantly Associated with Schizophrenia in Han Chinese. Biological Psychiatry. 2010 Oct 1;68(7):671-3.

24.    Hu X, Liu Q, Zhang Z, Li Z, Wang S, He L^*, Shi Y^*. SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder. Cell Research. 2010 Jul;20(7):854-7.

25.    Shi YY^*, He G^*, Zhang Z, Tang W, Zhang J, Zhao Q, Zhang J, Li XW, Xi ZR, Fang C, Zhao XZ, Feng GY, He L^*. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Molecular Psychiatry. 2008 Oct;13(10):911-3.

26.    Ye Z, Li Z, Wang Y, Mao Y, Shen M, Zhang Q, Li S, Zhou L, Shou X, Chen J, Song Z, Ma Z, Zhang Z, Li Y, Ye H, Huang C, Wang T, He W, Zhang Y, Xie R, Qiao N, Qiu H, Huang S, Wang M, Shen J, Wen Z, Li W, Liu K, Zhou J, Wang L, Ji J, Wang Y, Chen H, Cheng H, Shi Z, Zhu Y, Geng D, Yao Z, Tang W, Lu B, Pan L, Zhang Y, Bao W, Wu J, Zheng K, Shi Y^*, Zhao Y^*. Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma. Nature Genetics. 2015 Jul;47(7):793-7. doi: 10.1038/ng.3322.

27.    Hu Z^*, Liu Y, Zhai X, Dai J, Jin G, Wang L, Zhu L, Yang Y, Liu J, Chu M, Wen J, Xie K, Du G, Wang Q, Zhou Y, Cao M, Liu L, He Y, Wang Y, Zhou G, Jia W, Lu J, Li S, Liu J, Yang H, Shi Y^*, Zhou W^*, Shen H^*. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nature Genetics. 2013 Dec;45(12):1499-503. doi: 10.1038/ng.2809.

28.    Chen ZJ^*, Zhao H, He L, Shi Y, Qin Y, Shi Y^*, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics. 2011 Jan;43(1):55-9.

29.    Zhu M, Yan C, Ren C, Huang X, Zhu X, Gu H, Wang M, Wang S, Gao Y, Ji Y, Miao X, Yang M, Chen J, Du J, Huang T, Jiang Y, Dai J, Ma H, Zhou J, Wang Z, Hu Z, Ji G, Zhang Z, Shen H^*, Shi Y^*, Jin G^*. Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer. Gastroenterology. 2017 Jun;152(8):2011-2021.

30.    Gao Q, Wang ZC, Duan M, Lin YH, Zhou XY, Worthley DL, Wang XY, Niu G, Xia Y, Deng M, Liu LZ, Shi JY, Yang LX, Zhang S, Ding ZB, Zhou J, Liang CM, Cao Y, Xiong L, Xi R, Shi YY^*, Fan J^*. Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents. Gastroenterology. 2017 Jan;152(1):232-242.e4.

31.    Zheng R, Li Z, He F, Liu H, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B, Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, Feng Y, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S, Shi Y^*, Ge B^*. Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. Nature Communications. 2018 Oct 4;9(1):4072

32.    Zhang H, Chao J^*, Pan D, Liu H, Qiang Y, Liu K, Cui C, Chen J, Huang Q, Hu J, Wang L, Huang W, Shi Y^*, Fan C^*. DNA origami-based shape IDs for single-molecule nanomechanical genotyping. Nature Communications. 2017 Apr 6;8:14738. doi: 10.1038/ncomms14738.

33.    Song ZJ, Reitman ZJ, Ma ZY, Chen JH, Zhang QL, Shou XF, Huang CX, Wang YF, Li SQ, Mao Y, Zhou LF, Lian BF, Yan H, Shi YY^*, Zhao Y^*. The genome-wide mutational landscape of pituitary adenomas. Cell Research. 2016 Nov;26(11):1255-1259. doi: 10.1038/cr.2016.114.

34.    Ma ZY, Song ZJ, Chen JH, Wang YF, Li SQ, Zhou LF, Mao Y, Li YM, Hu RG, Zhang ZY, Ye HY, Shen M, Shou XF, Li ZQ, Peng H, Wang QZ, Zhou DZ, Qin XL, Ji J, Zheng J, Chen H, Wang Y, Geng DY, Tang WJ, Fu CW, Shi ZF, Zhang YC, Ye Z, He WQ, Zhang QL, Tang QS, Xie R, Shen JW, Wen ZJ, Zhou J, Wang T, Huang S, Qiu HJ, Qiao ND, Zhang Y, Pan L, Bao WM, Liu YC, Huang CX, Shi YY^*, Zhao Y^*. Recurrent gain-of-function USP8 mutations in Cushing's disease. Cell Research. 2015 Mar;25(3):306-17. doi: 10.1038/cr.2015.20.

35.    Li Z^*, Liu HL, Chen J, Zeng T, He L, Li M, Luo C, Liu S, Ding TT, Yimaiti K, Teng J, Li X, Ding Y, Cheng X, Zhou J, Ye J, Ji J, Su YT, Shi H, Sun Y, Gao C, Hu Q, Chi H, Yuan X, Zhou Z, Wang D, Wang K, Li CG, Sun Y, Niu Y, Chen LJ, Xu J, Wu L, Zhou Z, Pan D, Niu H^*, Shi Y^*, Yang C^*. Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals. Annals of the Rheumatic Diseases. 2019 Aug 30.

36.    Hu Z#, Shi Y#, Mo X, Xu J, Zhao B, Lin Y, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen H. A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nature Genetics. 2013 May 26;45(7):818-21. doi: 10.1038/ng.2636.

37.    Tang RQ^#, Zhao XZ^#, Shi YY^#, Tang W, Gu NF, Feng GY, Xing YL, Zhu SM, Sang H, Liang PJ, He L. Family-based association study of Epsin 4 and Schizophrenia. Molecular Psychiatry. 2006, 11(4), 395-9.

* Corresponding Author / ^# Co-first Author

任中国生物信息学学会（筹）多组学与整合生物学专委会委员，生物工程学会计算生物学与生物信息学专委会委员，人工智能学会生物信息与人工生命专委会委员，教育部第五轮学科评估专家，获 SMC-上海交通大学晨星优秀青年学者奖励、上海交通大学烛光优秀教师二等奖等荣誉。主要从事生物信息学和系统生物学方面的研究，以多组学大数据与人工智能为利器解析复杂疾病发生发展机制。近年来发表SCI论文40余篇。主持国家自然基金、上海市自然基金、教育部留学回国人员基金等。

1. 多组学大数据与复杂生物网络整合的方法学研究

2. 基于组学特征和机器学习方法发掘肿瘤、精神疾病等的分子分型与诊疗靶点

3. 基于调控与代谢网络整合模型指导合成生物学理性设计

1)    Peike Wu; Renliang Sun; Aamir Fahira; Yongzhou Chen; Huiting Jiangzhou; Ke Wang; Qiangzhen Yang; Yang Dai; Dun Pan; Yongyong Shi; Zhuo Wang*. DROEG: a method for cancer drug response prediction based on omics and essential genes integration. Briefings in Bioinformatics, 2023, bbad003. IF 13.994

2)    Zhuo Wang#, Xiuxia Yuan#，Zijia Zhu#, Lijuan Pang#, Shizhi Ding, Xue Li, Yulin Kang, Gangrui Hei, Liyuan, Zhang, Xiaoyun Zhang, Shuying Wang, Xuemin Jian, Zhiqiang Li, Chenxiang Zheng, Xiaoduo Fan, Shaohua Hu, Yongyong Shi*, and Xueqin Song*. Multiomics Analyses Reveal Microbiome–Gut–Brain Crosstalk Centered on Aberrant GABA and Tryptophan Metabolism in Drug-naïve Patients with First-episode Schizophrenia. Schizophrenia Bulletin, 2023, sbad026.  IF 7.348

3)   Qiangzhen Yang; Disong Xia; Ali Alamdar Shah Syed; Zhuo Wang; Yongyong Shi. Highly accurate protein structure prediction and drug screen of Monkeypox virus proteome. Journal of Infection,2023,86: 66–117. IF 38.637

4)   Huiting Jiangzhou; Hang Zhang; Renliang Sun; Aamir Fahira; Ke Wang; Zhiqiang Li; Yongyong Shi*; Zhuo Wang*. Integrative omics analysis reveals effective stratification and potential prognosis markers of pan-gastrointestinal cancers. iScience, 2021, 24(8): 0-102824. IF 6.107

5)    Yuming Liu#; Jinmai Zhang#; Zhuo Wang#; Jiaqiang Ma; Ke Wang; Dongning Rao; Mao Zhang; Youpei Lin; Yingcheng Wu; Zijian Yang; Liangqing Dong; Zhenbin Ding; Xiaoming Zhang; Jia Fan; Yongyong Shi*; Qiang Gao*. Multi-omics characterization reveals the pathogenesis of liver focal nodular hyperplasia. iScience, 2022, 25(9): 104921-104921. IF 6.107

6)   Yuechun Yu; Ke Wang; Aamir Fahira; Qiangzhen Yang; Renliang Sun; Zhiqiang Li; Zhuo Wang*; Yongyong Shi*. Systematic comparative study of computational methods for HLA typing from next-generation sequencing. HLA, 2021, 97(6): 481-492. IF 8.762

7)    Renliang Sun; Yizhou Xu; Hang Zhang; Qiangzhen Yang; Ke Wang; Yongyong Shi*; Zhuo Wang*. Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma. Frontiers in Genetics, 2020, 11: 0-595242. IF 4.772

8)   Fangzhou Shen; Renliang Sun; Jian Li; Nathan D. Price; Chenguang Liu; Qian Liu; Jie Yao; Zhuo Wang*. OptRAM: In-silico strain design via integrative regulatory-metabolic network modeling, PLOS Computational Biology, 2019, 15(3). IF 4.801

9)    Zhang, Hang; Wang, Ke; Zhou, Juan; Chen, Jianhua; Xu, Yizhou; Wang, Dong; Li, Xiaoqi; Sun, Renliang; Zhang, Mancang; Zhuo Wang*; Yongyong Shi*. VariFAST: A variant filter by automated scoring based on tagged-signatures. BMC Bioinformatics, 2019, 20: 0-713. IF 3.242

10)  Zhuo Wang; Samuel A Danziger; Benjamin D Heavner; Shuyi Ma; Jennifer J Smith; Song Li; Thurston Herricks; Evangelos Simeonidis; Nitin S Baliga; John D Aitchison; Nathan D Price; Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast, PLoS Computational Biology, 2017, 13(5): 0-e1005489. IF 4.801

#并列第一作者 *通讯作者

1.       Zhang M*, Wu S*, Du S*, Qian W*, Chen J, et. al. Genetic variants underlying differences in facial morphology in East Asian and European populations. Nature Genetics. 2022. Apr; 54(4):403-411. （IF=41.307）

2.       Qian W*, Zhang M*, Wan K*, Xie Y*, Du S, et. al. Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness. Journal of Genetics and Genomics. 2022. Mar 5:S1673-8527(22)00072-8. （IF=5.723）

3.       Wu S*, Zhang M*, Yang X*, Peng F, Zhang J, et. al. Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLOS Genetics. 2018 Sep 24; 14(9):e1007640. （IF=6.02）

4.       Zhang M*, Li B*, Wu S, Tan J, Yang Y, et. al. A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function. Journal of Investigative Dermatology. 2017 Apr; 137(4):979-982. （IF=7.59）

5.       Zhang M*, Wu S*, Zhang J*, Yang Y*, Tan J, et. al. Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. Journal of Genetics and Genomics. 2016 Dec 20;43(12):702-704. （IF=5.723）

6.       Wang CC*, Yeh HY*, Popov AN*, Zhang HQ*, Matsumura H, … , Zhang M, He G, Yang X, Hu R, Robbeets M, Schiffels S, Kennett DJ, Jin L, Li H, Krause J, Pinhasi R, Reich D. Genomic insights into the formation of human populations in East Asia. Nature. 2021 Mar; 591(7850):413-419. （IF=69.504）

7.       Huang Y*, Li D*, Qiao L, Liu Y, Peng Q, Wu S, Zhang M, et. al. A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese. Journal of Genetics and Genomics. 2021 Mar 20; 48(3):198-207. （IF=5.723）

8.       Wu S*, Tan J*, Yang Y*, Peng Q, Zhang M, et. al. Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Human Genetics. 2016 Nov; 135(11):1279-1286. （IF=5.881）

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