学习工作经历：

2023至今    中国科学院脑科学与智能技术卓越创新中心副主任（主持工作）；

2022至今    上海交通大学Bio-X研究院院长；

2022至今    Progress in Neuropsychopharmacology & Biological Psychiatry杂志副主编

2019 ~ 2024 上海交通大学生命科学技术学院副院长；

2018至今    “Research”杂志副主编；

2014至今    上海交通大学特聘教授（Distinguished Professor）；

2014 ~ 2024 “Hereditas”杂志主编；

2019 ~ 2022 上海交通大学Bio-X研究院执行院长；

2008 ~ 2013, 上海交通大学研究员;

2006 ~ 2008, 上海交通大学副教授;

学术兼职：Research杂志（AAAS）副主编、Progress in Neuropsychopharmacology & Biological Psychiatry杂志副主编、Hereditas杂志十年主编（2014-2024）、中国遗传学会理事、上海市遗传学会理事会理事、上海市神经科学学会理事。

获得荣誉：谈家桢生命科学奖创新奖等，上海市科技精英、上海市青年科技杰出贡献奖、首届教育部青年科学奖等，首批中组部青年拔尖人才，中青年科技创新领军人才，上海市十大杰出青年等，上海市优秀学术带头人，全国优秀博士论文，教育部新世纪优秀人才，上海市青年科技英才，上海市曙光学者，上海市科技启明星，霍英东青年教师奖，明治生命科学奖等。

科研业绩：承担国自然重点项目、863计划重大专项、973青年科学家项目、科技部重点研发项目等。发表SCI论文300余篇，总引用超2.4万次，H-Index 67（Google Scholar）；2019年至今持续入选爱思唯尔高被引学者；以通讯作者和（或）第一作者身份在 《Nature Nanotechnology》、 《Nature Genetics》、《Cell Research》杂志上发表了19篇论文；以第一完成人身份获得国家自然科学二等奖1项、上海市自然科学奖一等奖1项、教育部自然科学一等奖1项，并以第一发明人身份取得了23项发明专利（10项美国专利）和3项软件著作权授权。

脑疾病分子机理；基因组学、神经科学、生物信息学、合成生物学交叉学科领域

1.        Zhao H^#*, Xu Y^#, Xue B^#, Zhao S^#, Zhang M^#, Wu X, Wang T, Wen Y, Li S, Zhang Q, Yang Z, Sun H, Pan T, Lian Y, Gao X, Gao C, Wang Z, Wu C, Zhang C, Jian X, Peng L, Zhang X, Wang B, Wei L, He Y, Xia Y, Wu Z, Yang Q, Sun Y, Ding Y, Du S, Xia G, Jing Y, Xu H, Shi W, Liu J, He L, Chen Z, Cao Y^*, Li Z^*, Shi Y^*. New Insights into Genetic Susceptibility of Polycystic Ovary Syndrome. Nature Genetics. 2025 Nov; 57:2669-2681.

2.        Li Z, Chen J, Yu H, He L, Xu Y, Zhang D, Yi Q, Li C, Li X, Shen J, Song Z, Ji W, Wang M, Zhou J, Chen B, Liu Y, Wang J, Wang P, Yang P, Wang Q, Feng G, Liu B, Sun W, Li B, He G, Li W, Wan C, Xu Q, Li W, Wen Z, Liu K, Huang F, Ji J, Ripke S, Yue W, Sullivan P, Donovan M, Shi Y^*. Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nature Genetics. 2017 Nov;49(11):1576-1583.

3.        Lam M^#, Chen CY^#, Li Z, Martin AR, Bryois J, Ma X, Gaspar H, Ikeda M, Benyamin B, Brown BC, Liu R, Zhou W, Guan L, Kamatani Y, Kim SW, Kubo M, Kusumawardhani AAAA, Liu CM, Ma H, Periyasamy S, Takahashi A, Xu Z, Yu H, Zhu F; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Indonesia Schizophrenia Consortium; Genetic REsearch on schizophreniA neTwork-China and the Netherlands (GREAT-CN), Chen WJ, Faraone S, Glatt SJ, He L, Hyman SE, Hwu HG, McCarroll SA, Neale BM, Sklar P, Wildenauer DB, Yu X, Zhang D, Mowry BJ, Lee J, Holmans P, Xu S, Sullivan PF, Ripke S, O'Donovan MC, Daly MJ, Qin S, Sham P, Iwata N, Hong KS, Schwab SG, Yue W^*, Tsuang M^*, Liu J^*, Ma X^*, Kahn RS^*, Shi Y^*, Huang H^*. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics. 2019 Dec;51(12):1670-1678.

4.        Xu H, Liu F, Li Z, Li X, Liu Y, Li N, Zhang X, Gao Z, Zhang X, Liu Y, Zou J, Meng L, Liu S, Zhu H, Tang X, Wu H, Su K, Chen B, Yu D, Ye H, Chen H, Yi H, Guan J^*, Yin S^*, Shi Y^*. Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-Related Traits Identifies Novel Risk Loci in Han Chinese Individuals. American Journal of Respiratory and Critical Care Medicine. 2022 Jul 12. doi: 10.1164/rccm.202109-2044OC.

5.        Chang K, Jian X, Wu C, Gao C, Li Y, Chen J, Xue B, Ding Y, Peng L, Wang B, He L, Xu Y, Li C, Li X, Wang Z, Zhao X, Pan D, Yang Q, Zhou J, Zhu Z, Liu Z, Xia D, Feng G, Zhang Q, Wen Y, Shi Y^*, Li Z^*. The Contribution of Mosaic Chromosomal Alterations to Schizophrenia. Biological Psychiatry. 2025 Jan 15; 97(2):198-207. doi: 10.1016/j.biopsych.

6.        Yang Q, Xia D, Syed AAS, Wang Z, Shi Y^*. Highly accurate protein structure prediction and drug screen of monkeypox virus proteome. Journal of Infection. 2022 Aug 11: S0163-4453(22)00470-4.

7.        Yang Q, Jian X, Syed AAS, Fahira A, Zheng C, Zhu Z, Wang K, Zhang J, Wen Y, Li Z, Pan D, Lu T, Wang Z, Shi Y^*. Structural Comparison and Drug Screening of Spike Proteins of Ten SARS-CoV-2 Variants. Research (Wash D C). 2022 Feb 1;2022:9781758. doi: 10.34133/2022/9781758. eCollection 2022.

8.        Yang Q, Syed AAS, Fahira A, Shi Y^*. Structural Analysis of the SARS-CoV-2 Omicron Variant Proteins. Research (Wash D C). 2021 Dec 28;2021:9769586. doi: 10.34133/2021/9769586. eCollection 2021.

9.        Shi YY, He L^*. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Research. 2005, 15(2), 97-8.

10.    Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, He L^*, Shi Y^*. A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (http://analysis.bio-x.cn). Cell Research. 2009 Apr;19(4):519-23.

11.    Chen P, Pan D, Fan C^*, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y^*. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nature Nanotechnology. 2011 Sep 4;6(10):639-44. doi: 10.1038/nnano.2011.141.

12.    Shi Y^*, Li Z, Xu Q, Wang T, Li T, Shen J, Zhang F, Chen J, Zhou G, Ji W, Li B, Xu Y, Liu D, Wang P, Yang P, Liu B, Sun W, Wan C, Qin S, He G, Steinberg S, Cichon S, Werge T, Sigurdsson E, Tosato S, Palotie A, Nöthen MM, Rietschel M, Ophoff RA, Collier DA, Rujescu D, Clair DS, Stefansson H, Stefansson K, Ji J, Wang Q, Li W, Zheng L, Zhang H, Feng G, He L^*. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genetics. 2011 Oct 30;43(12):1224-7. doi: 10.1038/ng.980.

13.    Shi Y^*, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D^*, Shen H^*. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nature Genetics. 2011 Oct 30;43(12):1215-8. doi: 10.1038/ng.978.

14.    Shi Y^*, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y, Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X^*, Ma D^*. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. Nature Genetics. 2013 Aug;45(8):918-22. doi: 10.1038/ng.2687. Epub 2013 Jun 30.

15.    Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L^*, Chen ZJ^*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics. 2012 Sep;44(9):1020-5.

16.    Chen J, Jian X, Deng S, Ma Z, Shou X, Shen Y, Zhang Q, Song Z, Li Z, Peng H, Peng C, Chen M, Luo C, Zhao D, Ye Z, Shen M, Zhang Y, Zhou J, Fahira A, Wang Y, Li S, Zhang Z, Ye H, Li Y, Shen J, Chen H, Tang F, Yao Z, Shi Z, Chen C, Xie L, Wang Y, Fu C, Mao Y, Zhou L, Gao D, Yan H, Zhao Y^*, Huang C^*, Shi Y^*. Identification of recurrent USP48 and BRAF mutations in Cushing's disease. Nature Communications. 2018 Aug 9;9(1):3171.

17.    Li Z, Chen J, Zhao Y, Wang Y, Xu J, Ji J, Shen J, Zhang W, Chen Z, Sun Q, Mao L, Cheng S, Yang B, Zhang D, Xu Y, Zhao Y, Liu D, Shen Y, Zhang W, Li C, Shen J, Shi Y^*. Common variants in ZMIZ1 and near NGF confer risk for primary dysmenorrhoea. Nature Communications. 2017 Apr 27;8:14900. doi: 10.1038/ncomms14900.

18.    Li Z, Chen J, Xu Y, Yi Q, Ji W, Wang P, Shen J, Song Z, Wang M, Yang P, Wang Q, Feng G, Liu B, Sun W, Xu Q, Li B, He L, He G, Li W, Wen Z, Liu K, Huang F, Zhou J, Ji J, Li X, Shi Y^*. Genome-wide Analysis of the Role of Copy Number Variation in Schizophrenia Risk in Chinese. Biological Psychiatry. 2016 Aug 15;80(4):331-7. doi: 10.1016/j.biopsych.2015.11.012.

19.    Li C^*, Li Z, Liu S, Wang C, Han L, Cui L, Zhou J, Zou H, Liu Z, Chen J, Cheng X, Zhou Z, Ding C, Wang M, Chen T, Cui Y, He H, Zhang K, Yin C, Wang Y, Xing S, Li B, Ji J, Jia Z, Ma L, Niu J, Xin Y, Liu T, Chu N, Yu Q, Ren W, Wang X, Zhang A, Sun Y, Wang H, Lu J, Li Y, Qing Y, Chen G, Wang Y, Zhou L, Niu H, Liang J, Dong Q, Li X, Mi QS, Shi Y^*. Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese. Nature Communications. 2015 May 13;6:7041. doi: 10.1038/ncomms8041.

20.    Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y^*. Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population. Molecular Psychiatry. 2011 May;16(5):473-5.

21.    Li J, Zhou G, Ji W, Feng G, Zhao Q, Liu J, Li T, Li Y, Chen P, Zeng Z, Wang T, Hu Z, Zheng L, Wang Y, Shen Y, He L, Shi Y^*. Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia. Archives of General Psychiatry. 2011 Mar;68(3):232-40.

22.    Shi Y, Zhao X, Yu L, Tao R, Tang J, La Y, Duan Y, Gao B, Gu N, Xu Y, Feng G, Zhu S, Liu H, Salter H, He L. Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. Genome Research. 2004, 14(7), 1345-9.

23.    Li T, Li Z, Chen P, Zhao Q, Wang T, Huang K, Li J, Li Y, Liu J, Zeng Z, Feng G, He L, Shi Y^*. Common Variants in Major Histocompatibility Complex Region and TCF4 Gene Are Significantly Associated with Schizophrenia in Han Chinese. Biological Psychiatry. 2010 Oct 1;68(7):671-3.

24.    Hu X, Liu Q, Zhang Z, Li Z, Wang S, He L^*, Shi Y^*. SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk genetic epistasis in bipolar disorder. Cell Research. 2010 Jul;20(7):854-7.

25.    Shi YY^*, He G^*, Zhang Z, Tang W, Zhang J, Zhao Q, Zhang J, Li XW, Xi ZR, Fang C, Zhao XZ, Feng GY, He L^*. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Molecular Psychiatry. 2008 Oct;13(10):911-3.

26.    Ye Z, Li Z, Wang Y, Mao Y, Shen M, Zhang Q, Li S, Zhou L, Shou X, Chen J, Song Z, Ma Z, Zhang Z, Li Y, Ye H, Huang C, Wang T, He W, Zhang Y, Xie R, Qiao N, Qiu H, Huang S, Wang M, Shen J, Wen Z, Li W, Liu K, Zhou J, Wang L, Ji J, Wang Y, Chen H, Cheng H, Shi Z, Zhu Y, Geng D, Yao Z, Tang W, Lu B, Pan L, Zhang Y, Bao W, Wu J, Zheng K, Shi Y^*, Zhao Y^*. Common variants at 10p12.31, 10q21.1 and 13q12.13 are associated with sporadic pituitary adenoma. Nature Genetics. 2015 Jul;47(7):793-7. doi: 10.1038/ng.3322.

27.    Hu Z^*, Liu Y, Zhai X, Dai J, Jin G, Wang L, Zhu L, Yang Y, Liu J, Chu M, Wen J, Xie K, Du G, Wang Q, Zhou Y, Cao M, Liu L, He Y, Wang Y, Zhou G, Jia W, Lu J, Li S, Liu J, Yang H, Shi Y^*, Zhou W^*, Shen H^*. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nature Genetics. 2013 Dec;45(12):1499-503. doi: 10.1038/ng.2809.

28.    Chen ZJ^*, Zhao H, He L, Shi Y, Qin Y, Shi Y^*, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics. 2011 Jan;43(1):55-9.

29.    Zhu M, Yan C, Ren C, Huang X, Zhu X, Gu H, Wang M, Wang S, Gao Y, Ji Y, Miao X, Yang M, Chen J, Du J, Huang T, Jiang Y, Dai J, Ma H, Zhou J, Wang Z, Hu Z, Ji G, Zhang Z, Shen H^*, Shi Y^*, Jin G^*. Exome Array Analysis Identifies Variants in SPOCD1 and BTN3A2 That Affect Risk for Gastric Cancer. Gastroenterology. 2017 Jun;152(8):2011-2021.

30.    Gao Q, Wang ZC, Duan M, Lin YH, Zhou XY, Worthley DL, Wang XY, Niu G, Xia Y, Deng M, Liu LZ, Shi JY, Yang LX, Zhang S, Ding ZB, Zhou J, Liang CM, Cao Y, Xiong L, Xi R, Shi YY^*, Fan J^*. Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents. Gastroenterology. 2017 Jan;152(1):232-242.e4.

31.    Zheng R, Li Z, He F, Liu H, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B, Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, Feng Y, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S, Shi Y^*, Ge B^*. Genome-wide association study identifies two risk loci for tuberculosis in Han Chinese. Nature Communications. 2018 Oct 4;9(1):4072

32.    Zhang H, Chao J^*, Pan D, Liu H, Qiang Y, Liu K, Cui C, Chen J, Huang Q, Hu J, Wang L, Huang W, Shi Y^*, Fan C^*. DNA origami-based shape IDs for single-molecule nanomechanical genotyping. Nature Communications. 2017 Apr 6;8:14738. doi: 10.1038/ncomms14738.

33.    Song ZJ, Reitman ZJ, Ma ZY, Chen JH, Zhang QL, Shou XF, Huang CX, Wang YF, Li SQ, Mao Y, Zhou LF, Lian BF, Yan H, Shi YY^*, Zhao Y^*. The genome-wide mutational landscape of pituitary adenomas. Cell Research. 2016 Nov;26(11):1255-1259. doi: 10.1038/cr.2016.114.

34.    Ma ZY, Song ZJ, Chen JH, Wang YF, Li SQ, Zhou LF, Mao Y, Li YM, Hu RG, Zhang ZY, Ye HY, Shen M, Shou XF, Li ZQ, Peng H, Wang QZ, Zhou DZ, Qin XL, Ji J, Zheng J, Chen H, Wang Y, Geng DY, Tang WJ, Fu CW, Shi ZF, Zhang YC, Ye Z, He WQ, Zhang QL, Tang QS, Xie R, Shen JW, Wen ZJ, Zhou J, Wang T, Huang S, Qiu HJ, Qiao ND, Zhang Y, Pan L, Bao WM, Liu YC, Huang CX, Shi YY^*, Zhao Y^*. Recurrent gain-of-function USP8 mutations in Cushing's disease. Cell Research. 2015 Mar;25(3):306-17. doi: 10.1038/cr.2015.20.

35.    Li Z^*, Liu HL, Chen J, Zeng T, He L, Li M, Luo C, Liu S, Ding TT, Yimaiti K, Teng J, Li X, Ding Y, Cheng X, Zhou J, Ye J, Ji J, Su YT, Shi H, Sun Y, Gao C, Hu Q, Chi H, Yuan X, Zhou Z, Wang D, Wang K, Li CG, Sun Y, Niu Y, Chen LJ, Xu J, Wu L, Zhou Z, Pan D, Niu H^*, Shi Y^*, Yang C^*. Both HLA class I and II regions identified as genome-wide significant susceptibility loci for adult-onset Still's disease in Chinese individuals. Annals of the Rheumatic Diseases. 2019 Aug 30.

36.    Hu Z#, Shi Y#, Mo X, Xu J, Zhao B, Lin Y, Yang S, Xu Z, Dai J, Pan S, Da M, Wang X, Qian B, Wen Y, Wen J, Xing J, Guo X, Xia Y, Ma H, Jin G, Yu S, Liu J, Zhou Z, Wang X, Chen Y, Sha J, Shen H. A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nature Genetics. 2013 May 26;45(7):818-21. doi: 10.1038/ng.2636.

37.    Tang RQ^#, Zhao XZ^#, Shi YY^#, Tang W, Gu NF, Feng GY, Xing YL, Zhu SM, Sang H, Liang PJ, He L. Family-based association study of Epsin 4 and Schizophrenia. Molecular Psychiatry. 2006, 11(4), 395-9.

* Corresponding Author / ^# Co-first Author

担任中国人工智能学会生物信息与人工生命专委会委员，中国生物工程学会计算生物学与生物信息学专委会委员，ISCB-China首届理事，上海市生物信息学会理事。主要从事生物信息学、AI赋能的精准医学与合成生物学研究，包括多组学整合方法、基因组-表型组关联研究、多组学解析精神疾病机制、AI指导代谢网络设计等。近年来以第一作者/通讯作者身份发表论文50余篇，主持国家级项目3项，上海市项目3项，作为课题负责人承担国家重点研发课题1项，作为骨干参与重点研发3项。授权专利3项，软件著作权3项，实审状态专利2项，参编教材专著3部。获得上海交通大学晨星优秀青年学者，烛光优秀教师等荣誉。

1. 多组学大数据与复杂生物网络整合的方法学研究

2. 基于跨尺度多组学特征和AI模型发掘肿瘤、精神疾病等的分子分型与诊疗靶点

3. 基于AI与数字细胞模型整合指导合成生物学理性设计

1)    Wang Zhuo#, Yuan Xiuxia#， Zhu Zijia #, Pang Lijuan#, Ding Shizhi, Li Xue, Kang Yulin, Hei Gangrui, Zhang Liyuan, Zhang Xiaoyun, Wang Shuying, Jian Xuemin, Li Zhiqiang, Zheng Chenxiang, Fan Xiaoduo, Hu Shaohua, Shi Yongyong*, and Song Xueqin*. Multiomics Analyses Reveal Microbiome–Gut–Brain Crosstalk Centered on Aberrant GABA and Tryptophan Metabolism in Drug-naïve Patients with First-episode Schizophrenia. Schizophrenia Bulletin, 2024, 50(1):187–198.

2)    Zhu Z#, Wang Z#*, Yuan X, Zou Y, Zheng C, Wen Y, Hei G, Song X*, Shi Y*. Multimodal neuroimaging reveals brain neurochemical disturbances associated with superoxide dismutase in first-episode drug-naïve schizophrenia. Transl Psychiatry. 2026 Jan 5;16(1):19. doi: 10.1038/s41398-025-03801-w. PMID: 41490977; PMCID: PMC12804751.

3)    Wu Peike, Sun Renliang, Fahira Aamir, Chen Yongzhou, Jiangzhou Huiting,Wang Ke, Yang Qiangzhen, Dai Yang, Pan Dun, Shi Yongyong, Wang Zhuo*. DROEG: a method for cancer drug response prediction based on omics and essential genes integration. Briefings in Bioinformatics, 2023, bbad003.

4)   Jiangzhou Huiting^#, Xu Hanpeng^#, Wen Yanqin, Guan Zeyi, Zheng Yang, Jian Xuemin, Song Weichen, Fahira Aamir, Zhang Jinmai, Zhang Qing, Zhao Ying, Zhang Manfei, Chen Jianhua, Li Zhiqiang, Wang Zhuo*, Shi Yongyong*. Association between primary dysmenorrhea and mental health traits: a study based on multi-phenotype correlation network and mendelian randomization analysis in female college students. Phenomics, 2025, 1-16.

5)  Yang Qiangzhen, Xia Disong, Shah Syed Ali Alamdar, Wang Zhuo, Shi Yongyong*. Highly accurate protein structure prediction and drug screen of Monkeypox virus proteome. Journal of Infection 2022, doi: https://doi.org/10.1016/j.jinf.2022.08.006

6)    Liu Yuming ^#, Zhang Jinmai ^#, Wang Zhuo ^#, Ma Jiaqiang, Wang Ke, Rao Dongning, Zhang Mao, Lin Youpei, Wu Yingcheng, Yang Zijian, Dong Liangqing, Ding Zhenbin, Zhang Xiaoming, Fan Jia, Shi Yongyong *, and Gao Qiang *. Multi-omics characterization reveals the pathogenesis of liver focal nodular hyperplasia. iScience 2022, 25, 104921.

7)  Jiangzhou Huiting, Zhang Hang, Sun Renliang, Fahira Aamir, Wang Ke, Li Zhiqiang, Shi Yongyong*, Wang Zhuo*. Integrative Omics Analysis Reveals Effective Stratification and Potential Prognosis Markers of Pan-Gastrointestinal Cancers. iScience. 2021, 24(8): 0-102824.

8)    Yu Yuechun, Wang Ke, Fahira Aamir, Yang Qiangzhen, Sun Renliang, Li Zhiqiang, Wang Zhuo*, Shi Yongyong*. Systematic comparative study of computational methods for HLA typing from next-generation sequencing. HLA, 2021,97(6), 481–492.

9） Shen Fangzhou, Sun Renliang, Yao Jie, Li Jian, Price Nathan, Liu Qian, Liu Chenguang, Wang Zhuo*. OptRAM: In-silico strain design via integrative regulatory-metabolic network modeling, PLOS Computational Biology. 2019, 15(3): e1006835.

#并列第一作者 *通讯作者

1.       Zhang M*, Wu S*, Du S*, Qian W*, Chen J, et. al. Genetic variants underlying differences in facial morphology in East Asian and European populations. Nature Genetics. 2022. Apr; 54(4):403-411. （IF=41.307）

2.       Qian W*, Zhang M*, Wan K*, Xie Y*, Du S, et. al. Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness. Journal of Genetics and Genomics. 2022. Mar 5:S1673-8527(22)00072-8. （IF=5.723）

3.       Wu S*, Zhang M*, Yang X*, Peng F, Zhang J, et. al. Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLOS Genetics. 2018 Sep 24; 14(9):e1007640. （IF=6.02）

4.       Zhang M*, Li B*, Wu S, Tan J, Yang Y, et. al. A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function. Journal of Investigative Dermatology. 2017 Apr; 137(4):979-982. （IF=7.59）

5.       Zhang M*, Wu S*, Zhang J*, Yang Y*, Tan J, et. al. Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. Journal of Genetics and Genomics. 2016 Dec 20;43(12):702-704. （IF=5.723）

6.       Wang CC*, Yeh HY*, Popov AN*, Zhang HQ*, Matsumura H, … , Zhang M, He G, Yang X, Hu R, Robbeets M, Schiffels S, Kennett DJ, Jin L, Li H, Krause J, Pinhasi R, Reich D. Genomic insights into the formation of human populations in East Asia. Nature. 2021 Mar; 591(7850):413-419. （IF=69.504）

7.       Huang Y*, Li D*, Qiao L, Liu Y, Peng Q, Wu S, Zhang M, et. al. A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese. Journal of Genetics and Genomics. 2021 Mar 20; 48(3):198-207. （IF=5.723）

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9.       Peng Q*, Li J*, Tan J*, Yang Y*, Zhang M, et. al. EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Human Genetics. 2016 Jan; 135(1):99-108. （IF=5.881）

以小鼠、非人灵长类等动物模型进行神经/精神疾病的机制研究。主持或参与重庆市自然科学基金面上项目，上海教委国际合作项目，国家科技部重点研发项目，医工交叉青年项目等项目。

目前主要利用疾病人群iPSC，基因编辑，类器官，模式生物，分子生物学，生物化学，分子与细胞成像，电生理，空间转录等技术，开展以下方向的工作：

1. 易感基因对精神分裂症的影响。通过从疾病人群中筛选出来的精神疾病易感基因，我们发现了一个转录因子辅助因子能够通过抑制单神经元放电的模式介导精神分裂症的负性症状。接下来我们还将进一步定位该基因的亚细胞定位，明确其神经活动的功能。

2. 急性应激对抑郁情绪发生的影响。我们通过前期人群研究，结合模式生物，发现了一个在急性应激后被甲基化调控的基因，通过影响少突胶质细胞的成熟过程，影响抑郁情绪的发生。

3. 易感基因调控帕金森样运动障碍的发生的机制。我们在小鼠中条件性敲除了一个人群中发现的运动障碍易感基因，发现能导致小鼠发生PD样的运动障碍。在特异性脑区，我们发现特异类型细胞的异常死亡。

•  Ni J, Ren S, Hu Y, Ma D, Kuang Y^#, Yoshimura N. Water-avoidance stress aggravates prostatic inflammation in a murine model of chronic prostatitis. Neurourol Urodyn. 2024 Jun 7. doi: 10.1002/nau.25518. Epub ahead of print. （唯一通讯作者）
•  Ma D^*, Kuang Y^{*, #}, Lan Z, Zeng S, Li Y, Shang Y, Zhang R, Wang L, Zhao B^#, Li W ^#. The rapid change in mental health among college students after introduction of on-campus quarantine during the 2022 Shanghai COVID-19 lockdown. Front Public Health. 2023 May 5;11:1132575.(带教学生第一) （共同通讯、共同一作）
• Kuang Y^*, Xu C^*, Zhang Y, Wang Y, Wu X, Wang Y, Liu Y, Zhong K, Cheng Hui, Guo Yi, Wang S, Ding M, and Zhong C. Low-frequency stimulation of the primary focus retards positive transfer of secondary focus. Scientific reports. 2017 Mar 23;7(1):345.（第一作者）
• Cheng H^*, Kuang Y^*, Liu Y, Wang Y, Xu Z, Gao F, Zhang S, Ding M and Chen Z. Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats. Acta Pharmacologica Sinica. 2015 Aug; 36(8):957-65.（共同一作）
• Chen L, Li Y, Liu M, Lan Z, Zhang X, Yang X, Zhao Q, Wang S, Xu L, Zhou Y, Kuang Y, Suzuki T, Tabuchi K, Takahashi E, Zhou M, Chen CD, Xu T, Li W. Desipramine reverses remote memory deficits by activating calmodulin-CaMKII pathway in a UTX knockout mouse model of Kabuki syndrome. Gen Psychiatr. 2024 Oct 29;37(5)
•  Chen Z, Wang Z, Shen Y, Zeng S, Yang X, Kuang Y, Dou Z, Wang L, Li W. Face-specific negative bias of aesthetic perception in depression: Behavioral and EEG evidence. Front Psychiatry. 2023 Feb 6;14:1102843.
• Yang X, Chen Z, Wang Z, He G, Li Z, Shi Y, Gong N, Zhao B, Kuang Y, Takahashi E, Li W. A natural marmoset model of genetic generalized epilepsy. Mol Brain. 2022 Feb 10;15(1):16.
• Liu Z, Li C, Fan X, Kuang Y, Zhang X, Chen L, Song J, Zhou Y, Takahashi E, He G, Li W. Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice. Mol Brain. 2020 Nov 23;13(1):162.
• Song J, Yang X, Zhou Y, Chen L, Zhang X, Liu Z, Niu W, Zhan N, Fan X, Khan A, Kuang Y, Song L, He G, Li W. Dysregulation of neuron differentiation in an autistic savant with exceptional memory. Molecular Brain. 2019 Nov 7;12(1):91.
• Yang Y, Guo Y, Kuang Y, Wang S, Jiang Y, Ding Y, Wang S, Ding M. Serotonin 1A receptor inhibits the status epilepticus induced by lithium-pilocarpine in rats. Neuroscience Bulletin. 2014 Jun; 30(3):401-8.
• Wang Y, Liang J, Cenglin Xu, Wang Y, Kuang Y, Xu Z, Guo Y, Wang S, Gao F, and Chen Z. Low-frequency stimulation of anterior thalamus alleviates kainite-induced chronic epilepsy and modulates of the hippocampal EEG rhythm. Experimental Neurology. 2016 Feb; 276:22-30.