教育部长江学者特聘教授，国家杰出青年基金获得者，中组部青年拔尖人才，教育部新世纪优秀人才，上海市青年科技英才，上海市科技启明星，全国优秀博士论文获得者；国家自然科学基金重点项目、国家863计划重大项目等课题负责人；中国遗传学会青年委员会委员，上海市遗传学会理事，Experimental Biology and Medicine杂志编委；发表SCI论文100余篇，总影响因子超过1000，总他引2000余次。

课题组主要研究方向为疾病、行为等人类复杂性状的遗传学研究，涉及分子遗传学、生物信息学、纳米科学、发育生物学等领域。

1.Chen P, Pan D, Fan C*, Chen J, Huang K, Wang D, Zhang H, Li Y, Feng G, Liang P, He L, Shi Y*. Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nature Nanotechnology. 2011 Sep 4;6(10):639-44. doi: 10.1038/nnano.2011.141. (IF: 30.324)

2. Shi Y*, Li L, Hu Z, Li S, Wang S, Liu J, Wu C, He L, Zhou J, Li Z, Hu T, Chen Y, Jia Y, Wang S, Wu L, Cheng X, Yang Z, Yang R, Li X, Huang K, Zhang Q, Zhou H, Tang F, Chen Z, Shen J, Jiang J, Ding H, Xing H, Zhang S, Qu P, Song X, Lin Z, Deng D, Xi L, Lv W, Han X, Tao G, Yan L, Han Z, Li Z, Miao X, Pan S, Shen Y, Wang H, Liu D, Gong E, Li Z, Zhou L, Luan X, Wang C, Song Q, Wu S, Xu H, Shen J, Qiang F, Ma G, Liu L, Chen X, Liu J, Wu J, Shen Y, Wen Y, Chu M, Yu J, Hu X, Fan Y, He H, Jiang Y, Lei Z, Liu C, Chen J, Zhang Y, Yi C, Chen S, Li W, Wang D, Wang Z, Di W, Shen K, Lin D, Shen H, Feng Y, Xie X*, Ma D*. A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12. Nature Genetics. 2013 Aug;45(8):918-22. doi: 10.1038/ng.2687. Epub 2013 Jun 30. (IF: 36.377)

3.Shi Y*, Hu Z, Wu C, Dai J, Li H, Dong J, Wang M, Miao X, Zhou Y, Lu F, Zhang H, Hu L, Jiang Y, Li Z, Chu M, Ma H, Chen J, Jin G, Tan W, Wu T, Zhang Z, Lin D*, Shen H*. A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. Nature Genetics. 2011 Oct 30;43(12):1215-8. doi: 10.1038/ng.978. (IF: 36.377)

4.Shi Y*, Li Z, Xu Q, Wang T, Li T, Shen J, Zhang F, Chen J, Zhou G, Ji W, Li B, Xu Y, Liu D, Wang P, Yang P, Liu B, Sun W, Wan C, Qin S, He G, Steinberg S, Cichon S, Werge T, Sigurdsson E, Tosato S, Palotie A, Nöthen MM, Rietschel M, Ophoff RA, Collier DA, Rujescu D, Clair DS, Stefansson H, Stefansson K, Ji J, Wang Q, Li W, Zheng L, Zhang H, Feng G, He L*. Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nature Genetics. 2011 Oct 30;43(12):1224-7. doi: 10.1038/ng.980. (IF: 36.377)

5.Shi Y, Zhao H, Shi Y, Cao Y, Yang D, Li Z, Zhang B, Liang X, Li T, Chen J, Shen J, Zhao J, You L, Gao X, Zhu D, Zhao X, Yan Y, Qin Y, Li W, Yan J, Wang Q, Zhao J, Geng L, Ma J, Zhao Y, He G, Zhang A, Zou S, Yang A, Liu J, Li W, Li B, Wan C, Qin Y, Shi J, Yang J, Jiang H, Xu JE, Qi X, Sun Y, Zhang Y, Hao C, Ju X, Zhao D, Ren CE, Li X, Zhang W, Zhang Y, Zhang J, Wu D, Zhang C, He L*, Chen ZJ*. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nature Genetics. 2012 Aug 12. doi: 10.1038/ng.2384. [Epub ahead of print] (IF: 36.377)

6.Li J, Zhou G, Ji W, Feng G, Zhao Q, Liu J, Li T, Li Y, Chen P, Zeng Z, Wang T, Hu Z, Zheng L, Wang Y, Shen Y, He L, Shi Y*. Common Variants in the BCL9 Gene Conferring Risk of Schizophrenia. Archives of General Psychiatry. 2011 Mar;68(3):232-40. (IF: 15.618)

7. Zeng Z, Wang T, Li T, Li Y, Chen P, Zhao Q, Liu J, Li J, Feng G, He L, Shi Y*. Common SNPs and haplotypes in DGKH are associated with bipolar disorder and schizophrenia in the Chinese Han population. Molecular Psychiatry. 2011 May;16(5):473-5. (IF: 15.470)

8.Chen ZJ*, Zhao H, He L, Shi Y, Qin Y, Shi Y*, Li Z, You L, Zhao J, Liu J, Liang X, Zhao X, Zhao J, Sun Y, Zhang B, Jiang H, Zhao D, Bian Y, Gao X, Geng L, Li Y, Zhu D, Sun X, Xu JE, Hao C, Ren CE, Zhang Y, Chen S, Zhang W, Yang A, Yan J, Li Y, Ma J, Zhao Y. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nature Genetics. 2011 Jan;43(1):55-9. (IF: 36.377)

9.Hu Z*, Liu Y, Zhai X, Dai J, Jin G, Wang L, Zhu L, Yang Y, Liu J, Chu M, Wen J, Xie K, Du G, Wang Q, Zhou Y, Cao M, Liu L, He Y, Wang Y, Zhou G, Jia W, Lu J, Li S, Liu J, Yang H, Shi Y*, Zhou W*, Shen H*. New loci associated with chronic hepatitis B virus infection in Han Chinese. Nature Genetics. 2013 Oct 27. doi: 10.1038/ng.2809. [Epub ahead of print] (IF: 36.377)

10. Shi YY*, He G*, Zhang Z, Tang W, Zhang J, Zhao Q, Zhang J, Li XW, Xi ZR, Fang C, Zhao XZ, Feng GY, He L*. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Molecular Psychiatry. 2008 Oct;13(10):911-3. (IF: 15.470)

#并列第一作者 *通讯作者

任中国生物信息学学会（筹）多组学与整合生物学专委会委员，生物工程学会计算生物学与生物信息学专委会委员，人工智能学会生物信息与人工生命专委会委员，教育部第五轮学科评估专家，获 SMC-上海交通大学晨星优秀青年学者奖励、上海交通大学烛光优秀教师二等奖等荣誉。主要从事生物信息学和系统生物学方面的研究，以多组学大数据与人工智能为利器解析复杂疾病发生发展机制。近年来发表SCI论文40余篇。主持国家自然基金、上海市自然基金、教育部留学回国人员基金等，子课题主持3项国家重点研发计划项目。

1. 多组学大数据与复杂生物网络整合的方法学研究

2. 基于组学特征和机器学习方法发掘肿瘤、精神疾病等的分子分型与诊疗靶点

3. 基于调控与代谢网络整合模型指导合成生物学理性设计

1)    Peike Wu; Renliang Sun; Aamir Fahira; Yongzhou Chen; Huiting Jiangzhou; Ke Wang; Qiangzhen Yang; Yang Dai; Dun Pan; Yongyong Shi; Zhuo Wang*. DROEG: a method for cancer drug response prediction based on omics and essential genes integration. Briefings in Bioinformatics, 2023, bbad003. IF 13.994

2)    Zhuo Wang#, Xiuxia Yuan#，Zijia Zhu#, Lijuan Pang#, Shizhi Ding, Xue Li, Yulin Kang, Gangrui Hei, Liyuan, Zhang, Xiaoyun Zhang, Shuying Wang, Xuemin Jian, Zhiqiang Li, Chenxiang Zheng, Xiaoduo Fan, Shaohua Hu, Yongyong Shi*, and Xueqin Song*. Multiomics Analyses Reveal Microbiome–Gut–Brain Crosstalk Centered on Aberrant GABA and Tryptophan Metabolism in Drug-naïve Patients with First-episode Schizophrenia. Schizophrenia Bulletin, 2023, sbad026.  IF 7.348

3)   Qiangzhen Yang; Disong Xia; Ali Alamdar Shah Syed; Zhuo Wang; Yongyong Shi. Highly accurate protein structure prediction and drug screen of Monkeypox virus proteome. Journal of Infection,2023,86: 66–117. IF 38.637

4)   Huiting Jiangzhou; Hang Zhang; Renliang Sun; Aamir Fahira; Ke Wang; Zhiqiang Li; Yongyong Shi*; Zhuo Wang*. Integrative omics analysis reveals effective stratification and potential prognosis markers of pan-gastrointestinal cancers. iScience, 2021, 24(8): 0-102824. IF 6.107

5)    Yuming Liu#; Jinmai Zhang#; Zhuo Wang#; Jiaqiang Ma; Ke Wang; Dongning Rao; Mao Zhang; Youpei Lin; Yingcheng Wu; Zijian Yang; Liangqing Dong; Zhenbin Ding; Xiaoming Zhang; Jia Fan; Yongyong Shi*; Qiang Gao*. Multi-omics characterization reveals the pathogenesis of liver focal nodular hyperplasia. iScience, 2022, 25(9): 104921-104921. IF 6.107

6)   Yuechun Yu; Ke Wang; Aamir Fahira; Qiangzhen Yang; Renliang Sun; Zhiqiang Li; Zhuo Wang*; Yongyong Shi*. Systematic comparative study of computational methods for HLA typing from next-generation sequencing. HLA, 2021, 97(6): 481-492. IF 8.762

7)    Renliang Sun; Yizhou Xu; Hang Zhang; Qiangzhen Yang; Ke Wang; Yongyong Shi*; Zhuo Wang*. Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma. Frontiers in Genetics, 2020, 11: 0-595242. IF 4.772

8)   Fangzhou Shen; Renliang Sun; Jian Li; Nathan D. Price; Chenguang Liu; Qian Liu; Jie Yao; Zhuo Wang*. OptRAM: In-silico strain design via integrative regulatory-metabolic network modeling, PLOS Computational Biology, 2019, 15(3). IF 4.801

9)    Zhang, Hang; Wang, Ke; Zhou, Juan; Chen, Jianhua; Xu, Yizhou; Wang, Dong; Li, Xiaoqi; Sun, Renliang; Zhang, Mancang; Zhuo Wang*; Yongyong Shi*. VariFAST: A variant filter by automated scoring based on tagged-signatures. BMC Bioinformatics, 2019, 20: 0-713. IF 3.242

10)  Zhuo Wang; Samuel A Danziger; Benjamin D Heavner; Shuyi Ma; Jennifer J Smith; Song Li; Thurston Herricks; Evangelos Simeonidis; Nitin S Baliga; John D Aitchison; Nathan D Price; Combining inferred regulatory and reconstructed metabolic networks enhances phenotype prediction in yeast, PLoS Computational Biology, 2017, 13(5): 0-e1005489. IF 4.801

#并列第一作者 *通讯作者

1.       Zhang M*, Wu S*, Du S*, Qian W*, Chen J, et. al. Genetic variants underlying differences in facial morphology in East Asian and European populations. Nature Genetics. 2022. Apr; 54(4):403-411. （IF=41.307）

2.       Qian W*, Zhang M*, Wan K*, Xie Y*, Du S, et. al. Genetic evidence for facial variation being a composite phenotype of cranial variation and facial soft tissue thickness. Journal of Genetics and Genomics. 2022. Mar 5:S1673-8527(22)00072-8. （IF=5.723）

3.       Wu S*, Zhang M*, Yang X*, Peng F, Zhang J, et. al. Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. PLOS Genetics. 2018 Sep 24; 14(9):e1007640. （IF=6.02）

4.       Zhang M*, Li B*, Wu S, Tan J, Yang Y, et. al. A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function. Journal of Investigative Dermatology. 2017 Apr; 137(4):979-982. （IF=7.59）

5.       Zhang M*, Wu S*, Zhang J*, Yang Y*, Tan J, et. al. Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. Journal of Genetics and Genomics. 2016 Dec 20;43(12):702-704. （IF=5.723）

6.       Wang CC*, Yeh HY*, Popov AN*, Zhang HQ*, Matsumura H, … , Zhang M, He G, Yang X, Hu R, Robbeets M, Schiffels S, Kennett DJ, Jin L, Li H, Krause J, Pinhasi R, Reich D. Genomic insights into the formation of human populations in East Asia. Nature. 2021 Mar; 591(7850):413-419. （IF=69.504）

7.       Huang Y*, Li D*, Qiao L, Liu Y, Peng Q, Wu S, Zhang M, et. al. A genome-wide association study of facial morphology identifies novel genetic loci in Han Chinese. Journal of Genetics and Genomics. 2021 Mar 20; 48(3):198-207. （IF=5.723）

8.       Wu S*, Tan J*, Yang Y*, Peng Q, Zhang M, et. al. Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Human Genetics. 2016 Nov; 135(11):1279-1286. （IF=5.881）

9.       Peng Q*, Li J*, Tan J*, Yang Y*, Zhang M, et. al. EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects. Human Genetics. 2016 Jan; 135(1):99-108. （IF=5.881）