中国神经科学学会精神病学基础与临床分会委员，中国药理学会药物基因组学专业委员会委员，中国遗传学会伦理委员会委员。曾/正主持7项国家自然科学基金、3项国家科技重大专项/国家重点研发计划。

研究方向主要聚焦于精神疾病的生物学诊断、个性化治疗以及相关机制研究：

1. 在多种精神神经疾病中建立了基于烟酸皮肤反应表型的辅助诊断模型，鉴定了其在脑疾病生物学诊断领域的巨大临床转化潜力。并深入解析了该表型参与精神疾病病理的分子机制，对具有相同功能表征的疾病亚人群开发了分层干预和精准治疗策略。

2. 通过代谢组学、蛋白组学、转录组学等研究手段揭示了精神分裂症患者的代谢异常，并基于尿液、血浆、细胞膜、线粒体等生物样本阐释了脂质代谢紊乱，在复杂精神疾病的分子诊断标记物研究工作中取得了突破性进展。

1. Jinfeng Wang, Shuhui Li, Dandan Wang, Yan Gao, Qian Wang, Tianqi Wang, Guanghai Wang, Daihui Peng, Yi Qiao, Jiansong Zhou, Lei Feng, Xiaowen Hu*, Chunling Wan*. Effects of Omega-3 PUFAs on lipid profiles and antioxidant response in depressed adolescents: A metabolomic and lipidomic study. Redox Biology. 2025;82:103617.

2. Yan Gao, Dandan Wang, Qian Wang, Jinfeng Wang, Shuhui Li, Tianqi Wang, Xiaowen Hu*, Chunling Wan*. Causal Impacts of Psychiatric Disorders on Cognition and the Mediating Effect of Oxidative Stress: A Mendelian Randomization Study. Antioxidants. 2025 Jan 29;14(2):162.

3. Jinfeng Wang, Xiaowen Hu, Ya Li, Shuhui Li, Tianqi Wang, Dandan Wang, Yan Gao, Qian Wang, Jiansong Zhou*, Chunling Wan*. Impaired lipid homeostasis and elevated lipid oxidation of erythrocyte membrane in adolescent depression. Redox Biology. 2025;80:103491.

4. Jiang Jie, Wang Dandan, Gao Yan, Sun Liya, Li Shuhui, Hu Xiaowen, Li Zhuyun, Zhang Juan, Ji Feng, Tian Yusheng, Guan Lili, Li Zhiqiang, He Lin, Wan Chunling*. Altered HCAR3 expression may underlying the blunted niacin responses of the psychiatric disorders and the risk of schizophrenia. Psychiatry Clin Neurosci. 2024 Feb;78(2):123-130.

5. Li Minghui, Gao Yan, Wang Danan, Hu Xiaowen, Jiang Jie, Qing Ying, Yang Xuhan, Cui Gaoping, Wang Pengkun, Zhang Juan, Sun Liya*, Wan Chunling*. Impaired Membrane Lipid Homeostasis in Schizophrenia. Schizophrenia Bulletin**. 2022 Sep 1;48(5):1125-1135.

6. Yang Xuhan, Li Minghui, Jiang Jie, Hu Xiaowen, Qing Ying, Sun Liya, Yang Tianqi, Wang Dandan, Cui Gaoping, Gao Yan, Zhang Juan, Li Xingwang, Shen Yuhua, Qin Shengying, Wan Chunling*. Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia. EBioMedicine. 2021 Feb;64:103239.

7. Wang Dandan, Hu Xiaowen, Jiang Jie, Sun Liya, Qing Ying, Yang Xuhan, Gao Yan, Cui Gaoping, Li Minghui, Wang Pengkun, Zhang Juan, Zhuang Yan, Li Zezhi, Li Jing, Guan Lili, Zhang Tianhong, Wang Jijun, Ji Feng*, Wan Chunling*. Attenuated and delayed niacin skin flushing in schizophrenia and affective disorders: A potential clinical auxiliary diagnostic marker. Schizophrenia Research. 2021 Apr;230:53-60.

8. Cui Gaoping, Qing Ying, Hu Xiaowen, Wang Pengkun, Sun Liya, Yang Xuhan, Jiang Jie, Zhang Juan, Wang Hang, Feng Lei, Shen Yuhua, Qin Shengying, Wan Chunling*. Serum Metabolomic Profiling Based on Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry: Do the Dysfunctions of Metabolic Pathways Reveal a Universal Risk of Oxidative Stress in Schizophrenia? Antioxid Redox Signal. 2020 Oct 1;33(10):679-688. doi: 10.1089/ars.2020.8141. Epub 2020 Jul 23. PMID: 32578452.

9. Jiang Jie, Peng Chao, Sun Liya, Li Jing, Qing Ying, Hu Xiaowen, Yang Xuhan, Li Yan, Xu Chuangye, Zhang Juan, Min Jie, Li Xingwang, Qin Shengying, Lin Mei, Tan Liwen, Wan Chunling*. Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia? Antioxid Redox Signal. 2019 Sep 10;31(8):579-588.

10. Sun Liya, Yang Xuhan, Jiang Jie, Hu Xiaowen, Qing Ying, Wang Dandan, Yang Tianqi, Yang Chao, Zhang Juan, Yang Ping, Wang Peng, Cai Changqun, Wang Jijun, He Lin, Wan Chunling*. Identification of the niacin-blunted subgroup of schizophrenia patients from mood disorders and healthy individuals in Chinese population. Schizophrenia Bulletin. 2017 Oct 25;44(4):896-907.

*通讯作者