上海市科技启明星，上海医学会医学遗传学分会秘书。主持的973子课题已通过验收并评为“优”，主持一项国家自然基金项目、负责一项国际合作课题。参编专著、译著四部，发表SCI论文40多篇，第一作者和通讯作者论文他引次数超过160次。

精神疾病易感基因的研究，破解精神分裂症患者结直肠癌发生率低于正常之谜的初步研究，出生前营养不良导致精神分裂症的分子机制初探，揭示出生前营养不良导致成年后精神疾病发病风险增加的分子机制。

1. Wang Y, Zhang J, Liu B, Shao L, Wei Z, Li X, Ji J, Yang F, Wang T, Liu J, Wan C, Li B, Xu Y, Feng G, He L*, He G*. Genetic polymorphisms in the SCN8A gene are associated with suicidal behavior in psychiatric disorders in the Chinese population. World J Biol Psychiatry. 2010;11(8):956-63.

2. HTR2C promoter polymorphisms are associated with risperidone efficacy in Chinese female patients.Liu BC, Zhang J, Wang L, Li XW, Wang Y, Wei ZY, Ji J, Yang FP, Wan CL, Xu YF, Feng GY, He L*, He G*. Pharmacogenomics. 2010;11(5):685-92.

3. Shi YY*, He G*, Zhang Z, Tang W, Zhang J Jr, Zhao Q, Zhang J Sr, Li XW, Xi ZR, Fang C, Zhao XZ, Feng GY, He L*. A study of rare structural variants in schizophrenia patients and normal controls from Chinese Han population. Mol Psychiatry. 2008 Oct;13(10):911-3.

4. Zhang J, Shen Y, He G*, Li X, Meng J, Guo S, Li H, Gu N, Feng G, He L*. Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(2): 467-71.

5. He G#, Liu X#, Qin W, Chen Q, Wang X, Yang Y, Zhou J, Xu Y, Gu N, Feng G, Sang H, Wang P, He L*. MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese. Mol Psychiatry. 2006; 11(8):748-51.

6. Chen Q, He G, Qin W, Chen QY, Zhao XZ, Duan SW, Liu XM, Feng GY, Xu YF, St Clair D, Li M, Wang JH, Xing YL, Shi JG, He L*. Family-based association study of synapsin II and schizophrenia. Am J Hum Genet. 2004; 75(5):873-7.

#并列第一作者 *通讯作者

上海交通大学Bio-X研究院遗传资源中心副主任、设备委员会主任、硕导。2001年进入交大Bio-X研究院工作，先后参与了精神疾病及其他多项复杂人类遗传疾病的研究。作为主要科研骨干参与了多项国家863、973、自然科学基金资助项目、重大项目的研究以及与美国阿斯利康制药公司联合研究项目.作为子课题负责人承担863项目“人类遗传资源信息的数字化关键技术”，与胸科医院合作负责两项医工交叉项目。目前主要从事精神分裂症易感基因鉴定、精神疾病候选基因的相关分析及功能研究。以第一作者及共同作者发表SCI论文40余篇。

精神分裂症易感基因鉴定、复杂疾病候选基因的相关分析及功能研究。

1.Li X#, Wang Q#, He K, Li Z, Chen J, Li W, Wen Z, Shen J, Qiang Y, Ji J, Feng G, He G, Lin H, Wang Y, Shi Y. Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population. Behav Genet. 2014 Mar;44(2):97-101.

2.Xing-wangLi#, Bao-cheng Liu#, Yang Wang, Qing-zhu Zhao, Qi shen, Tao Yu, Shi-qing Chen, Feng-ping Yang, Wei-dongLi, Ling-han Gao, Yi-feng Xu, Guo-yin Feng, Lin He, Guang He. Association study on the DLG4 gene and schizophrenia in the Chinese Han population. Psychiatric Genetics. Psychiatr Genet. 2013 Dec;23(6):247-50.

3.Xing-wang Li#, Bao-cheng Liu#, Yang Wang, Qing-zhu Zhao, Qi shena, Shi-qing Chen, Jue Ji, Feng-ping Yang, Ling-han Gao, Yifeng Xu, Guo-yin Feng, Lin He, Guang He. NAPG may not a common risk gene shared by Bipolar Disorder and Schizophrenia in Chinese population. Psychiatric Genetics. 2012 Apr;22(2):107-8.

4.Xingwang Li#, Jing Zhang#, YangWang, Jue Ji, Fengping Yang, ChunlingWan, PengWang, Guoyin Feng, Klaus Lindpaintner, Lin He, Guang He. Association study on the NAPG gene and bipolar disorder in the Chinese Han population  Neuroscience Letters Neurosci Lett. 2009 Jul 3;457(3):159-62.

5.Zhang J#, Li X#, Wang Y, Ji J, Yang F, Feng G, Wan P, Lindpaintner K, He L, He G. Association study on the mitochondrial gene NDUFV2 and bipolar disorder in the Chinese Han population.  J Neural Transm. 2009 Mar;116(3):357-61.

#并列第一作者 *通讯作者

获得上海市浦江人才、上海交大晨星学者、莙政导师。博士毕业于加拿大Alberta大学AICML研究小组（AlphaGO摇篮），师从Dale Schuurmans院士和Guohui Lin教授。博士后受训于南加州大学分子与计算生物学院（USC-MCB），师从Jasmine Zhou教授、Frank Alber教授与Michael Waterman院士。主要从事计算生物学和人工智能研究，包括3D基因组与肿瘤和大脑遗传疾病的相关性研究、深度稀疏学习理论模型、个体化肿瘤mRNA疫苗、临床标志物发现、疾病早期预测等。主持科技部国际合作重点项目、国家自然科学基金青年项目、上海市人工智能重点专项等多个国家级与省部级项目。学术主页：http://yishi.sjtu.edu.cn

Machine learning in genetic diseases, cancer genetics and epigenetics, computational 3D genome, sparse learning, clinical bio-marker discovery, neo-antigen prediction (immunotherapy)

1.Z. Lu#, Q. Luo#, L. Zhao, Y. Shi, N. Wang, L. Wang, Z. Han*, The Mutational Features of Aristolochic Acid Induced Mouse and Human Liver Cancers, Hepatology, https://doi.org/10.1002/hep.30863, 2019

2.X. Su#*, Y. Shi#, R. Li#, Z. Lu#, X. Zou, J. Wu and Z. Han, Application of qPCR assays based on haloacids transporter gene dehp2 for discrimination of Burkholderia and Paraburkholderia, BMC Microbiology, 19:36, 2019.

3.Q. Hu, W. Gong, J. Gu, G. Geng, T. Li, R. Tian, Z. Yang, H. Zhang, L. Shao, T. Liu, L. Wan, J. Jia, C. Yang1*, Y. Shi* and H. Shi*, Plasma microRNA Profiles as a Potential Biomarker in Differentiating Adult-Onset Still's Disease From Sepsis, Frontiers in Immunology, 9(3099), 2019.

4.Y. Qu, C. Deng, Q. Luo, X. Shang, J. Wu, Y. Shi, L. Wang, Z. Han, Arid1a regulates insulin sensitivity and lipid metabolism, EBioMedicine, doi: https://doi.org/10.1016/j.ebiom.2019.03.021, 2019.

5.J.H. Lautaoja, M. Lalowski, T.A. Nissinen, J.J. Hentila, Y. Shi, O. Ritvos, S. Cheng, J.J. Hulmi, Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade, American Journal of Physiology: Endocrinology and Metabolism, 2019 Mar 12. doi:10.1152/ajpendo.00526. 2018.

6.Y. Yuan#*, Y. Shi#*, X. Su, X. Zou, Q. Luo, D.D. Feng, W. Cai*, and Z. Han*, Cancer Type Prediction based on Copy Number Aberration and Chromatin 3D Structure with Convolutional Neural Networks, BMC Genomics, 19:4919, 2018.

7.X. Zhang#, Y. Shi#, L. Song, C. Shen, Q. Cai, Z. Zhang, J. Wu, G. Fu*, W. Shen*, Identification of mutations in patients with acquired pure red cell aplasia, Acta Biochimica et Biophysica Sinica, 50(2):685-692, 2018.

8.X. Su#, Y. Shi#, X. Zou#, Z. Lu#, G. Xie, J.Y.H. Yang, C. Wu, X. Cui, K. He, Q. Luo, Y. Qu, N. Wang, L. Wang, and Z. Han*, Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development, BMC Genomics, 18:946, 2017.

9.L. Da*, Y. Shi, G. Ning, and J. Yu*, Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process, Nucleic Acids Research, 46(2):568-581, 2017.

10.Y. Yang, Y. Shi*, P. Wiklund, X. Tan, N. Wu, X. Zhang, O. Tikkanen, C. Zhang, E. Munukka and S. Cheng*, The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women, Nutrients, 9:792, doi:10.3390/nu9080792, 2017.

#并列第一作者 *通讯作者