国家级海外引进人才

2025至今   上海交通大学Bio-X研究院 长聘教轨副教授

2023-2025   昌平国家实验室 副研究员

2017-2023   斯坦福大学医学院 博士后

（Damon Runyon Cancer Research Foundation博士后基金，斯坦福大学Bio-X交叉种子项目基金）

恶性肿瘤转移的细胞分子机制研究，重点关注小细胞肺癌等侵袭性肿瘤的脑转移发生规律及靶向治疗策略。结合小鼠体内模型、体外类器官/三维仿生模型，运用多组学整合分析与细胞生物学技术，系统阐明脑转移肿瘤的发生发展机制以及对神经系统的影响。

1. Savchuk S, Gentry KM, Wang W, Carleton E, Biagi-Junior CAO, Luthria K, Yalçın B, Ni L, Farnsworth HC, Davis RA, Drexler R, Melms JC, Liu Y, Acosta-Alvarez L, Hartmann GG, Pavarino EC, LaBelle J, Woo PJ, Toland AM, Qu F, Kim YS, Filbin MG, Krasnow MA, Ligon KL, Izar B, Sage J, Sabatini BL, Monje M, Venkatesh HS. Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis. Nature. 2025 Oct;646(8087):1232-1242.

2. Chang J, Lu J, Liu Q, Xiang T, Zhang S, Yi Y, Li D, Liu T, Liu Z, Chen X, Dong Z, Li C, Yi H, Yu S, Huang L, Qu F, Wang M, Wang D, Dong H, Cheng G, Zhu L, Li J, Li C, Wu P, Xie X, Teschendorff AE, Lin D, Wang X, Wu C. Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis. Cancer Cell. 2025 Mar 10;43(3):380-397.e7.

3. Qu F, Brough SC, Michno W, Madubata CJ, Hartmann GG, Puno A, Drainas AP, Bhattacharya D, Tomasich E, Lee MC, Yang D, Kim J, Peiris-Pagès M, Simpson KL, Dive C, Preusser M, Toland A, Kong C, Das M, Winslow MM, Pasca AM, Sage J. Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis. Nat Cell Biol. 2023 Oct;25(10):1506-1519. 

4. Yang D, Qu F, Cai H, Chuang CH, Lim JS, Jahchan N, Grüner BM, S Kuo C, Kong C, Oudin MJ, Winslow MM, Sage J. Axon-like protrusions promote small cell lung cancer migration and metastasis. Elife. 2019 Dec 13;8:e50616. 

5. Qu F, Lorenzo DN, King SJ, Brooks R, Bear JE, Bennett V. Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. Elife. 2016 Oct 8;5:e20417.

上海交通大学助理研究员，博士毕业于上海交通大学，上海交通大学博士后，主要从事脑科学方向研究，以第一/通讯作者身份发表SCI论文6篇，获授权发明专利4项，主持博士后面上基金1项，重庆自然科学基金面上项目1项，参与国家重大科研项目5项。

负面情绪记忆消退的神经环路机制

脑转移肿瘤对神经系统的影响机制

(1) Zhang Xu, Lan Zhaohui, Huang Yu, Li Yuting, Wang Zhenbo, Sun Jingyu, Zhou Ying, Bao Hechen, Fan Xuelian, Yang Jiarun, Yang Xiujuan, Li Caiqin, Yang Xiangyu, Kuang Yifang, Zhou Miou, He Guang, Takahashi Eiki, Frankland Paul W., Li Weidong. Identification of somatostatin+ inhibitory engrams for extinction in the basolateral amygdala [J]. Proceedings of the National Academy of Sciences, 2026, 123(12): e2511528123.

(2) Gao Yuyun, Huang Yu#, Zhang Xu#. Estimating the subjective severity of laptop fan abnormal sounds using psychoacoustic parameters [J]. Applied Acoustics, 2025, 236: 110753.

(3) [1]     Ni Ke, Huang Yu, Wei Yi, Zhang Xu. Visual engagement modulates cortical criticality and auditory target detection thresholds in noisy soundscapes [J]. The Journal of the Acoustical Society of America, 2026, 159(3): 2513-25.

(4) Li Yuting*, Zhang Xu*, Xu Zhen, Chu Xixia, Hu Zhiqiang, Ye Zhengyang, Li Caiqin, Wang Zhenbo, Zeng Bin, Pan Jingyu, Zhao Qian, Zhou Chengbin, Lan Zhaohui, Kan Guanghan, He Guang, Xu Xiaodan, Li Weidong. Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque [J]. Molecular Brain, 2024, 17(1): 65.

(5) Zhang Xu; Chu Xixia; Chen Lei; Fu Juan; Wang Shuai; Song Jinjing; KanGuanghan; Jiang Weizhong; He Guang; Chen Xiaoping; Li Weidong; Simulated weightlessness procedure, head-down bedrest impairs adult neurogenesis in the hippocampus of rhesus macaque, Molecular Brain, 2019, 12.

(6) Jin Chunhui*; Zhang Xu*; Liu Xiaowei; Li Weidong; Zhang Fuquan; Yang Beimeng; Yuan Jianmin; Liu Liang; Cheng Zaohuo; Association study of KIBRA rs17070145 polymorphism with the risk of schizophrenia in the Han Chinese population, Psychiatry Research, 2016, 239: 331-332.